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在新处方避孕药使用者的多样化样本中,抑郁与避孕行为之间的关联。

The association between depression and contraceptive behaviors in a diverse sample of new prescription contraception users.

机构信息

Department of Family Science, University of Maryland School of Public Health, College Park, MD, United States.

Kaiser Permanente Northern California Division of Research, Oakland, CA, United States; Medicines360, San Francisco, CA, United States.

出版信息

Contraception. 2022 Jan;105:61-66. doi: 10.1016/j.contraception.2021.08.015. Epub 2021 Sep 2.

Abstract

OBJECTIVE

Among women initiating new prescription contraception, we investigated the relationship between recent depression and a range of contraceptive behaviors.

STUDY DESIGN

We used medical and pharmacy records of 52,325 women ages 19 to 29 who initiated prescription contraception (pills, patches or rings, injectables, and long-acting reversible contraceptives) in 2014-2016 at a large integrated healthcare system in Northern California. Women had continuous enrollment for a year before and after initiating, and no records of prescription contraceptive use in the year before initiating. Depression in the year prior to initiation was dichotomized into (1) no depression indicator (reference group) or (2) depression diagnosis or redeemed antidepressant. Multinomial logistic regression models examined the associations between depression and method type initiated, and contraceptive patterns, timing of discontinuation, inconsistent use, and switching methods over a year after initiating, adjusting for sociodemographics and testing for interactions between depression and having a recent birth or abortion.

RESULTS

Women with recent depression were more likely to initiate methods other than the pill, and the association was stronger for patches or rings vs pills among those with a recent birth compared to those without. Among women initiating all methods and the pill, those with depression were more likely to discontinue their method, use it inconsistently, and switch from it than use it continuously for a year.

CONCLUSION

Women with recent depression were less likely to initiate the pill; and when the pill was initiated, those with depression were more likely to discontinue use, use it inconsistently, and switch from it.

IMPLICATIONS

Women with recent depression indicators should be followed closely to ensure they have the support they need to meet their reproductive goals. Those who wish to avoid pregnancy may benefit from methods that do not require daily use.

摘要

目的

在开始使用新处方避孕药的女性中,我们研究了近期抑郁与一系列避孕行为之间的关系。

研究设计

我们使用了 2014 年至 2016 年在加利福尼亚州北部一家大型综合医疗保健系统中开始使用处方避孕药(药丸、贴片或环、注射剂和长效可逆避孕药)的 52325 名 19 至 29 岁女性的医疗和药房记录。女性在开始前和开始后连续一年入组,且在开始前一年无处方避孕药使用记录。在开始前一年的抑郁状态分为(1)无抑郁指标(参考组)或(2)抑郁诊断或使用抗抑郁药。多项逻辑回归模型检验了抑郁与开始使用的方法类型之间的关系,以及避孕模式、停药时间、使用不规律、以及在开始后一年内更换方法,调整了社会人口统计学因素,并检验了抑郁与最近分娩或流产之间的交互作用。

结果

近期有抑郁的女性更有可能开始使用除药丸以外的方法,与无近期分娩的女性相比,近期分娩的女性使用贴片或环的可能性更大。在开始使用所有方法和药丸的女性中,与连续使用一年的女性相比,抑郁的女性更有可能停止使用、不规律使用和更换方法。

结论

近期有抑郁指标的女性不太可能开始使用避孕药;当开始使用避孕药时,那些有抑郁的女性更有可能停止使用、不规律使用和更换。

意义

有近期抑郁指标的女性应密切随访,以确保她们得到满足其生殖目标所需的支持。那些希望避免怀孕的人可能会受益于不需要每日使用的方法。

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