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肺泡蛋白沉积症患者全肺灌洗术中应用肺部超声的麻醉管理:一例报告

Anesthetic management during whole-lung lavage using lung ultrasound in a patient with pulmonary alveolar proteinosis: a case report.

作者信息

Jung Jae Wan, Lee Hyunho, Oh Jimi

机构信息

Division of Pulmonary Medicine, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea.

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

出版信息

Yeungnam Univ J Med. 2021 Oct;38(4):374-380. doi: 10.12701/yujm.2021.01284. Epub 2021 Sep 6.

DOI:10.12701/yujm.2021.01284
PMID:34482678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8688793/
Abstract

Pulmonary alveolar proteinosis (PAP) is an uncommon disease characterized by progressive accumulation of lipoprotein material in the lungs due to impaired surfactant clearance. Whole-lung lavage (WLL) is the current standard treatment and consists of sequential lavage of each lung to mechanically remove the residual material from the alveoli. Although WLL is considered safe, unexpected complications can occur. Moreover, due to the rarity of the disease itself, this procedure is unknown to many physicians, and management of intraoperative complications can be challenging for anesthesiologists. Lung ultrasound (LUS) provides reliable and valuable information for detecting perioperative pulmonary complications and, in particular, quantitation of lung water content. There have been reports on monitoring the different stages of controlled deaeration of the non-ventilated lung during WLL using LUS. However, it has been limited to non-ventilated lungs. Therefore, we report the use of LUS in WLL to proactively detect pulmonary edema in the ventilated lung and implement a safe and effective anesthesia strategy. Given the limited diagnostic tools available to anesthesiologists in the operating room, LUS is a reliable, fast, and noninvasive method for identifying perioperative pulmonary complications in patients with PAP undergoing WLL.

摘要

肺泡蛋白沉积症(PAP)是一种罕见疾病,其特征是由于表面活性物质清除受损,脂蛋白物质在肺内进行性积聚。全肺灌洗(WLL)是目前的标准治疗方法,包括依次对每个肺进行灌洗,以机械方式清除肺泡内的残留物质。尽管WLL被认为是安全的,但仍可能发生意外并发症。此外,由于该疾病本身罕见,许多医生对该操作并不了解,麻醉医生处理术中并发症可能具有挑战性。肺部超声(LUS)为检测围手术期肺部并发症,尤其是定量肺含水量,提供了可靠且有价值的信息。已有关于在WLL期间使用LUS监测非通气肺控制性排气不同阶段的报道。然而,这些报道仅限于非通气肺。因此,我们报告在WLL中使用LUS来主动检测通气肺中的肺水肿,并实施安全有效的麻醉策略。鉴于手术室中麻醉医生可用的诊断工具有限,LUS是一种用于识别接受WLL的PAP患者围手术期肺部并发症的可靠、快速且无创的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/fb0db01734b3/yujm-2021-01284f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/b8727041512b/yujm-2021-01284f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/bacd844160ab/yujm-2021-01284f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/b69095ebc4df/yujm-2021-01284f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/fb0db01734b3/yujm-2021-01284f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/b8727041512b/yujm-2021-01284f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/bacd844160ab/yujm-2021-01284f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/b69095ebc4df/yujm-2021-01284f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003e/8688793/fb0db01734b3/yujm-2021-01284f4.jpg

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本文引用的文献

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J Cardiothorac Vasc Anesth. 2022 Feb;36(2):587-593. doi: 10.1053/j.jvca.2020.12.002. Epub 2020 Dec 5.
2
Whole lung lavage using a rapid infusion system to treat a patient with pulmonary alveolar proteinosis.使用快速输注系统进行全肺灌洗治疗肺泡蛋白沉积症患者。
Yeungnam Univ J Med. 2020 Jan;37(1):67-72. doi: 10.12701/yujm.2019.00360. Epub 2019 Oct 17.
3
Therapeutic Whole Lung Lavage for Alveolar Proteinosis.肺泡蛋白沉积症的治疗性全肺灌洗
J Cardiothorac Vasc Anesth. 2020 Jan;34(1):250-257. doi: 10.1053/j.jvca.2019.07.001. Epub 2019 Jul 29.
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Monitoring whole-lung lavage using lung ultrasound: The changing phases of the lung.使用肺部超声监测全肺灌洗:肺的变化阶段。
Lung India. 2018 Jul-Aug;35(4):350-353. doi: 10.4103/lungindia.lungindia_344_17.
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Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach.成人肺泡蛋白沉积症:病理生理学和临床方法。
Lancet Respir Med. 2018 Jul;6(7):554-565. doi: 10.1016/S2213-2600(18)30043-2. Epub 2018 Feb 1.
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