Section Molecular Virology, Institute for Medical Virology and Epidemiology, University Hospital Tübingen, Tübingen, Germany.
Section Molecular Virology, Institute for Medical Virology and Epidemiology, University Hospital Tübingen, Tübingen, Germany.
Trends Microbiol. 2022 Apr;30(4):364-378. doi: 10.1016/j.tim.2021.08.005. Epub 2021 Sep 2.
It is believed that hepatitis C virus (HCV) particles are released through the canonical secretory route: from the endoplasmic reticulum (ER), via the Golgi, to the plasma membrane. While the Golgi is important for HCV release per se, its direct involvement in the trafficking of assembled virions has not yet been established. In fact, data from studies analyzing HCV egress are compatible with several potential pathways of HCV secretion. Here, we summarize and discuss the current knowledge related to the HCV export pathway. Apart from the prototypical anterograde transport, possible routes of HCV release include ER-to-endosomal transport, secretory autophagy, and poorly described mechanisms of unconventional protein secretion. Studying HCV egress promises to shed light on unconventional cellular trafficking and secretory routes.
据信丙型肝炎病毒 (HCV) 颗粒通过经典的分泌途径释放：从内质网 (ER)，通过高尔基体，到质膜。虽然高尔基体本身对于 HCV 的释放很重要，但它在组装病毒粒子的运输中的直接参与尚未确定。事实上，分析 HCV 出芽的研究数据与 HCV 分泌的几种潜在途径是一致的。在这里，我们总结和讨论了与 HCV 输出途径相关的现有知识。除了典型的顺行运输外，HCV 释放的可能途径还包括 ER 到内体的运输、分泌自噬和描述不佳的非典型蛋白分泌机制。研究 HCV 出芽有望揭示非典型细胞运输和分泌途径。
