Department of Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom.
Department of Infectious Disease, Imperial College London, London, United Kingdom.
Clin J Sport Med. 2021 Nov 1;31(6):e470-e472. doi: 10.1097/JSM.0000000000000969.
Some groups of elite athletes have an apparent increased susceptibility to respiratory tract infection (RTI) with implications for their health and athletic performance. In this study, we aim to systemically evaluate vaccine response patterns as a potentially efficacious intervention strategy in elite athletes preparing for Olympic competition.
Cross-sectional observational study.
A UK Sport-funded Olympic training program.
One hundred twenty elite athletes and 10 matched healthy controls were studied. A subset of athletes were classified as RTI highly susceptible (n = 22), RTI nonsusceptible (n = 23), and asthmatic (n = 33), with matched controls also recruited (n = 10, 27 ± 3 years).
INTERVENTIONS/OUTCOME MEASURE: Serum samples were analysed from participants analysing enzyme-linked immunosorbent assay for Immunoglobulin G (IgG) responses against measles, mumps, rubella, and pneumococcus vaccines.
Although a majority of athletes (>90%) had detectable IgG levels against measles and rubella, only 76% had detectable mumps responses, with similar findings apparent in controls. Of those RTI-susceptible and asthmatic athletes, 22% had suboptimal antipneumococcal responses below 30 mg/L.
A significant proportion of elite athletes preparing for Olympic competition seem to be at risk of mumps infection. In addition, RTI-susceptible and asthmatic athletes exhibit suboptimal pneumococcal antibody responses, highlighting a need for prospective immune screening in athletes to ensure vaccination strategies are effectively delivered.
一些精英运动员群体明显更容易感染呼吸道感染（RTI），这对他们的健康和运动表现有影响。本研究旨在系统评估疫苗反应模式作为一种潜在有效的干预策略，用于准备参加奥运会的精英运动员。
横断面观察性研究。
英国体育资助的奥运训练计划。
120 名精英运动员和 10 名匹配的健康对照者进行了研究。一部分运动员被归类为 RTI 易感者（n=22）、RTI 不易感者（n=23）和哮喘者（n=33），并招募了匹配的对照者（n=10，27±3 岁）。
干预措施/结果测量：分析参与者的血清样本，采用酶联免疫吸附试验分析针对麻疹、腮腺炎、风疹和肺炎球菌疫苗的 IgG 反应。
尽管大多数运动员（>90%）对麻疹和风疹有可检测到的 IgG 水平，但只有 76%对腮腺炎有可检测到的反应，对照组也有类似的发现。在 RTI 易感和哮喘运动员中，22%的人对肺炎球菌的抗体反应不理想，低于 30mg/L。
准备参加奥运会的精英运动员中，相当一部分似乎面临着感染腮腺炎的风险。此外，RTI 易感和哮喘运动员的肺炎球菌抗体反应不理想，这表明需要对运动员进行前瞻性免疫筛查，以确保有效实施疫苗接种策略。
