Division of Gastroenterohepatology, Department of Internal Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Haji Adam Malik General Hospital, Medan Indonesia.
Med Arch. 2021 Jun;75(3):199-203. doi: 10.5455/medarh.2021.75.199-203.
Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis.
To evaluate the association between serum IL-6, IL-10, IL-12, and IL-23 levels and severity of liver cirrhosis.
This observational study was carried out at the Department of Internal Medicine, Universitas Sumatera Utara, Indonesia from March 2018 to August 2019. The severity of liver cirrhosis was assessed by using the Child-Pugh score. IL-6, IL-10, IL-12, and IL-23 levels, hepatitis and renal function were measured in all study subjects. Independent t-test and Mann-Whitney tests were conducted to observe differences between groups.
A total of 78 liver cirrhosis patients were enrolled, mean age was 50.6±11.4. Median serum IL-6, IL-10, IL-12, and IL-23 levels were 24.5(2.6-46.4)pg/ml, 2.1(0.4-9.3)pg/ml, 3.5(1.4-20.8)pg/ml and 20.3(9.2-218)pg/ml, respectively. A higher IL-6 level was associated with more severe liver cirrhosis (p=0.001) and the presence of hepatic encephalopathy (p=0.018). Higher IL-23 level was found in patients with no hepatic encephalopathy (p=0.049). There was no association between serum cytokines levels and hepatitis viral infection status.
IL-6 is associated with the severity of liver cirrhosis.
肝硬化在全球范围内导致高的肝脏相关死亡率。免疫细胞介导的全身炎症促进肝硬化的进展。越来越多的证据表明，几种促炎和抗炎细胞因子可能在肝硬化中起重要作用。
评估血清 IL-6、IL-10、IL-12 和 IL-23 水平与肝硬化严重程度的关系。
本观察性研究于 2018 年 3 月至 2019 年 8 月在印度尼西亚北苏门答腊大学内科进行。采用 Child-Pugh 评分评估肝硬化严重程度。在所有研究对象中测量了 IL-6、IL-10、IL-12 和 IL-23 水平、肝炎和肾功能。采用独立 t 检验和 Mann-Whitney 检验观察组间差异。
共纳入 78 例肝硬化患者，平均年龄为 50.6±11.4 岁。血清 IL-6、IL-10、IL-12 和 IL-23 水平中位数分别为 24.5(2.6-46.4)pg/ml、2.1(0.4-9.3)pg/ml、3.5(1.4-20.8)pg/ml 和 20.3(9.2-218)pg/ml。较高的 IL-6 水平与更严重的肝硬化（p=0.001）和肝性脑病的发生（p=0.018）相关。无肝性脑病的患者 IL-23 水平较高（p=0.049）。血清细胞因子水平与肝炎病毒感染状态之间无关联。
IL-6 与肝硬化的严重程度相关。
