单核苷酸多态性rs657152与新冠病毒病的病毒载量水平或东西伯利亚白种人群的患病概率无关。
SNP rs657152 Is Not Associated with the Level of Viral Load in COVID-19 or the Probability of Disease in the Population of Caucasians in Eastern Siberia.
作者信息
Orlova E A, Ogarkov O B, Khromova P A, Sinkov V V, Khasnatinov M A, Zhdanova S N, Rychkova L V, Kolesnikova L I
机构信息
Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia.
出版信息
Russ J Genet. 2021;57(8):982-984. doi: 10.1134/S1022795421080093. Epub 2021 Aug 30.
Cross-replicating associations with rs657152 at the 9q34.2c locus and rs11385942 at the 3p21.31 locus found in patients with severe COVID-19 in the Caucasian population require the study of the discovered phenomenon in various populations, including as an independent biological marker. Primers and TaqMan probes for PCR discrimination of the A and C alleles in single nucleotide polymorphism (SNP) rs657152 have been developed. The polymorphism of the rs657152 A/C locus was determined in 129 patients with COVID-19 and in a control group of 466 healthy individuals. There were no significant differences in the frequency of distribution of the A and C alleles, 0.47/0.53 and 0.45/0.55, between patients and healthy subjects, respectively. Also, no differences were found in the distribution of alleles in patients with a high viral load in the smear (Ct in the range of 16-25) in comparison with an average and low viral load (Ct in the range of 26-40).
在高加索人群中，重症COVID-19患者9q34.2c位点的rs657152和3p21.31位点的rs11385942存在交叉复制关联，这需要在包括作为独立生物标志物在内的不同人群中研究这一发现的现象。已开发出用于PCR鉴别单核苷酸多态性（SNP）rs657152中A和C等位基因的引物和TaqMan探针。在129例COVID-19患者和466名健康个体的对照组中确定了rs657152 A/C位点的多态性。患者和健康受试者中A和C等位基因的分布频率分别为0.47/0.53和0.45/0.55，无显著差异。此外，涂片病毒载量高（Ct在16 - 25范围内）的患者与平均和低病毒载量（Ct在26 - 40范围内）的患者相比，等位基因分布也没有差异。
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