Harper Ronald M, Hertling Dieter, Curtis Ashley, Sauerland Eberhardt K, De Giorgio Christopher M
Department of Neurobiology, David Geffen School of Medicine, Univeersity of California, Los Angeles, Los Angeles, CA, United States.
Department of Neurology, Olive View Medical Center, University of California, Los Angeles, Los Angeles, CA, United States.
Front Neurol. 2021 Aug 17;12:675947. doi: 10.3389/fneur.2021.675947. eCollection 2021.
Cerebellar stimulation reduces seizures in animals and in humans with drug-resistant epilepsy. In a pilot safety and feasibility study, we applied continuous cutaneous vibratory stimulation (limb proprioceptive cerebellar stimulation) to foot limb proprioceptive receptors to activate cerebellar, pontine, and thalamic structures in drug-resistant epilepsy patients for 8-h nocturnally up to 6-months after a 4-week pre-treatment control baseline. Seizure frequency was evaluated during the baseline control period, and at 6, 12, and 24 weeks after the control recordings. Five-subjects completed at least the first 6-week treatment. At 12-weeks, the median reduction in seizure frequency was -27.8% (mean reduction = -22.3%). Two subjects continued for 24 weeks, with a decline of -44.1 and -45.4%. This pilot study provides support for further clinical studies into the safety and efficacy of limb proprioceptive cerebellar stimulation for epilepsy.
小脑刺激可减少动物和耐药性癫痫患者的癫痫发作。在一项初步安全性和可行性研究中，我们对耐药性癫痫患者的足部肢体本体感受器施加持续的皮肤振动刺激（肢体本体感觉小脑刺激），以激活小脑、脑桥和丘脑结构，在为期4周的预处理对照基线期后，夜间进行8小时刺激，最长持续6个月。在基线对照期以及对照记录后的6周、12周和24周评估癫痫发作频率。五名受试者至少完成了前6周的治疗。在12周时，癫痫发作频率的中位数降低了-27.8%（平均降低=-22.3%）。两名受试者持续治疗24周，癫痫发作频率分别下降了-44.1%和-45.4%。这项初步研究为进一步开展关于肢体本体感觉小脑刺激治疗癫痫的安全性和有效性的临床研究提供了支持。
