ABL1是一种预后标志物，与肝细胞癌中的免疫浸润相关。

ABL1 Is a Prognostic Marker and Associated with Immune Infiltration in Hepatocellular Carcinoma.

作者信息

Liu Rongqiang, Kong Weihao, Jiang ZeKun, Zheng Shiyang, Yuan Xiaofeng, Ye Linsen

机构信息

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510220, Guangdong, China.

出版信息

J Oncol. 2021 Aug 26;2021:1379706. doi: 10.1155/2021/1379706. eCollection 2021.

DOI:10.1155/2021/1379706

PMID:34484330

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8413061/

Abstract

BACKGROUND

The role of ABL1 in hepatocellular carcinoma (HCC) is still unclear. Therefore, this study aims to explore the potential role of ABL1 in the progression of HCC using bioinformatics methods.

METHODS

We analyzed the expression, prognostic potential, and immune cell effect of ABL1 in HCC by using a variety of datasets.

RESULTS

ABL1 is highly expressed in HCC and associated with unfavorable overall survival (OS) and disease-free survival (DFS). Functional network analysis revealed that ABL1 plays an important role in mitochondrial activity, ATP metabolism, protein translation and metabolism, various neurological diseases, nonalcoholic fatty liver disease, and notch signaling pathway. In addition, we found that ABL1 expression was closely correlated with B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells. Furthermore, ABL1 expression was positively associated with the expression levels of immune checkpoint genes, such as PD-1L, TIM3, TIGIT, and CTLA4.

CONCLUSION

ABL1 is associated with immune infiltration and prognosis of HCC.

摘要

背景

ABL1在肝细胞癌（HCC）中的作用仍不明确。因此，本研究旨在运用生物信息学方法探索ABL1在HCC进展中的潜在作用。

方法

我们通过使用多种数据集分析了ABL1在HCC中的表达、预后潜力和免疫细胞效应。

结果

ABL1在HCC中高表达，且与不良的总生存期（OS）和无病生存期（DFS）相关。功能网络分析显示，ABL1在线粒体活性、ATP代谢、蛋白质翻译与代谢、各种神经疾病、非酒精性脂肪性肝病以及Notch信号通路中发挥重要作用。此外，我们发现ABL1表达与B细胞、CD8 + T细胞、CD4 + T细胞、巨噬细胞、中性粒细胞和树突状细胞密切相关。此外，ABL1表达与免疫检查点基因如PD-1L、TIM3、TIGIT和CTLA4的表达水平呈正相关。