Department of Biomedical Engineering, George Washington University, Washington, District of Columbia.
Division of Pulmonary Medicine, Department of Medicine, George Washington University, Washington, District of Columbia.
Physiology (Bethesda). 2022 Jan 1;37(1):39-45. doi: 10.1152/physiol.00023.2021. Epub 2021 Sep 6.
In this review we will briefly summarize the evidence that autonomic imbalance, more specifically reduced parasympathetic activity to the heart, generates and/or maintains many cardiorespiratory diseases and will discuss mechanisms and sites, from myocytes to the brain, that are potential translational targets for restoring parasympathetic activity and improving cardiorespiratory health.
在这篇综述中,我们将简要总结自主神经失衡(更具体地说是心脏副交感活动减少)产生和/或维持许多心肺疾病的证据,并讨论从心肌到大脑的潜在机制和靶点,这些靶点可能成为恢复副交感活动和改善心肺健康的治疗靶点。