Wu Chao
Peking University School of Nursing, Beijing, China.
J Appl Gerontol. 2022 Apr;41(4):971-981. doi: 10.1177/07334648211042370. Epub 2021 Sep 6.
The relationship between depression and age-related hearing loss (ARHL) is not fully understood. This study tested the bidirectional associations between clinically significant depressive symptoms (CSDSs) and ARHL in middle-aged and older adults using data from the China Health and Retirement Longitudinal Study. Among 3,418 participants free of baseline ARHL, baseline CSDS was associated with an increased odds of incident ARHL (odds ratio [OR]: 1.51). Cognitive decline, BMI, and arthritis partially mediated the longitudinal CSDS-ARHL association and explained 24% of the variance in the total effect. Among 4,921 participants without baseline CSDS, baseline ARHL was associated with an increased odds of incident CSDS (OR: 1.37). The bidirectional associations remained significant after adjustments for baseline demographic factors, comorbidities, and other health-related covariates. Depression may contribute to the development of ARHL, and vice versa. Interventions in depression, cognitive decline, and arthritis may delay the onset of ARHL and break the vicious circle between them.
抑郁症与年龄相关性听力损失（ARHL）之间的关系尚未完全明确。本研究利用中国健康与养老追踪调查的数据，对中老年人群中具有临床意义的抑郁症状（CSDSs）与ARHL之间的双向关联进行了检验。在3418名无基线ARHL的参与者中，基线CSDS与发生ARHL的几率增加相关（优势比[OR]：1.51）。认知功能下降、体重指数和关节炎部分介导了CSDS与ARHL之间的纵向关联，并解释了总效应中24%的变异。在4921名无基线CSDS的参与者中，基线ARHL与发生CSDS的几率增加相关（OR：1.37）。在对基线人口统计学因素、合并症和其他健康相关协变量进行调整后，双向关联仍然显著。抑郁症可能会促使ARHL的发生，反之亦然。对抑郁症、认知功能下降和关节炎进行干预可能会延缓ARHL的发病，并打破它们之间的恶性循环。
