Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Yanbian University, Yanji, China.
Department of Clinical Medicine, First School of Clinical Medicine, Nanchang University, Nanchang, China.
Front Public Health. 2024 Jan 8;11:1281689. doi: 10.3389/fpubh.2023.1281689. eCollection 2023.
Recently, the prevalence of sensorineural hearing loss (SNL) has been increasing, and several studies have suggested that depression, anxiety, and SNL may be associated with each other, however, individual findings still have discrepancies. To the best of our knowledge, no scholars have systematically elucidated the bidirectional associations between SNL, depression, and anxiety disorders from the perspective of meta-analysis. In this study, we aimed to systematically evaluate the bidirectional associations between SHL and depressive and anxiety symptoms, and to provide evidence-based medical evidence for reducing SNL, depression, and anxiety disorders.
We performed systematic review based on priori protocol that was registered with PROSPERO (No. CRD42022365963). Systematic search of PubMed, Embase, and Web of Science databases identified articles published as of June 1, 2023, on the relationship between SNL and depression and anxiety. Meta-analysis was performed to calculate the odds ratios (OR) and 95% confidence intervals (CIs) for the outcome metrics, and the results were combined to assess bivariate associations between the disorders with fixed or random effects. Sensitivity and subgroup analyzes were conducted to analyze sources of heterogeneity, and Egger's and Begg's tests combined with funnel plots were applied to assess publication bias.
Summary analysis of the results of 20 studies covering 675,291 individuals showed that the bidirectional association between SNL and depression and anxiety disorders. The incidence (OR = 0.17, 95% CI: 0.09-0.28) and risk (OR = 1.43, 95% CI: 1.32-1.55) of depression and morbidity were higher in SNL patients than the general population. Elevated prevalence (OR = 0.46, 95% CI: 0.28-0.65) and risk (OR = 1.30, 95% CI: 1.11-1.48) of SNL were also observed in depressed patients. The prevalence of anxiety disorders among SNL patients was about 40% (OR = 0.40, 95% CI: 0.24%-0.57), which was associated with higher risk (OR = 1.83, 95% CI: 1.42-2.24) of development than the general population. Incidence of SNL in patients with anxiety disorders was approximately 31% (OR = 0.31, 95% CI: 0.29-0.33). Additionally, subgroup analyzes showed that the bidirectional associations between SNL, depression, and anxiety disorders was influenced by age, region, and mode of diagnosis of the disorders (SNL, depression, anxiety).
There are bidirectional associations between SNL and depression and anxiety disorders, which was influenced by age and region and the method the disorders (SNL, depression, anxiety) were diagnosed.
最近，感音神经性听力损失（SNL）的患病率一直在上升，有几项研究表明，抑郁、焦虑和 SNL 可能相互关联，但个别研究结果仍存在差异。据我们所知，尚无学者从荟萃分析的角度系统阐明 SNL、抑郁和焦虑障碍之间的双向关联。在本研究中，我们旨在系统评估 SHL 与抑郁和焦虑症状之间的双向关联，并为降低 SNL、抑郁和焦虑障碍提供循证医学证据。
我们根据事先制定的方案进行了系统评价，该方案已在 PROSPERO（编号：CRD42022365963）上注册。系统检索了 PubMed、Embase 和 Web of Science 数据库，以获取截至 2023 年 6 月 1 日关于 SNL 与抑郁和焦虑关系的文章。Meta 分析用于计算结局指标的比值比（OR）和 95%置信区间（CI），并结合固定或随机效应来评估疾病之间的双向关联。进行敏感性和亚组分析以分析异质性的来源，并应用 Egger 和 Begg 检验结合漏斗图评估发表偏倚。
对涵盖 675,291 人的 20 项研究结果的综合分析表明，SNL 与抑郁和焦虑障碍之间存在双向关联。SNL 患者的抑郁发生率（OR=0.17，95%CI：0.09-0.28）和风险（OR=1.43，95%CI：1.32-1.55）以及发病率均高于普通人群。抑郁患者的 SNL 患病率（OR=0.46，95%CI：0.28-0.65）和风险（OR=1.30，95%CI：1.11-1.48）也有所升高。SNL 患者焦虑障碍的患病率约为 40%（OR=0.40，95%CI：0.24%-0.57%），这与发展风险较高（OR=1.83，95%CI：1.42-2.24）有关。焦虑障碍患者 SNL 的发病率约为 31%（OR=0.31，95%CI：0.29-0.33）。此外，亚组分析表明，SNL、抑郁和焦虑障碍之间的双向关联受年龄、地区和疾病诊断方式（SNL、抑郁、焦虑）的影响。
SNL 与抑郁和焦虑障碍之间存在双向关联，这种关联受年龄和地区以及 SNL、抑郁和焦虑障碍的诊断方式的影响。
