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本文引用的文献

1
Metabolomics: The Stethoscope for the Twenty-First Century.代谢组学：二十一世纪的听诊器。
Med Princ Pract. 2021;30(4):301-310. doi: 10.1159/000513545. Epub 2020 Dec 3.
2
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.时间进程代谢组学揭示糖尿病导致妊娠正常代谢转变发生改变。
Metabolites. 2020 Aug 27;10(9):350. doi: 10.3390/metabo10090350.
3
Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers.早产儿接受人乳或牛/驴乳基强化剂的尿液代谢组学特征。
Nutrients. 2020 Jul 27;12(8):2247. doi: 10.3390/nu12082247.
4
Untargeted lipidomics using liquid chromatography-ion mobility-mass spectrometry reveals novel triacylglycerides in human milk.采用液相色谱-离子淌度-质谱联用的非靶向脂质组学分析揭示了人乳中的新型三酰基甘油。
Sci Rep. 2020 Jun 9;10(1):9255. doi: 10.1038/s41598-020-66235-y.
5
Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study.妊娠糖尿病及向 2 型糖尿病进展过程中的氨基酸和脂质代谢：代谢组学研究。
PLoS Med. 2020 May 20;17(5):e1003112. doi: 10.1371/journal.pmed.1003112. eCollection 2020 May.
6
Integrated metabolome analysis reveals novel connections between maternal fecal metabolome and the neonatal blood metabolome in women with gestational diabetes mellitus.整合代谢组学分析揭示了妊娠糖尿病女性的母体粪便代谢组与新生儿血液代谢组之间的新联系。
Sci Rep. 2020 Feb 27;10(1):3660. doi: 10.1038/s41598-020-60540-2.
7
Early Human-Milk Metabolome in Cases of Intrauterine Growth-Restricted and Macrosomic Infants.宫内生长受限儿与巨大儿的早期人乳代谢组学研究
JPEN J Parenter Enteral Nutr. 2020 Nov;44(8):1510-1518. doi: 10.1002/jpen.1783. Epub 2020 Feb 5.
8
Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk.妊娠期糖尿病改变人初乳、过渡乳和成熟乳的代谢组。
Med Sci Monit. 2019 Aug 16;25:6128-6152. doi: 10.12659/MSM.915827.
9
Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands.危地马拉西部高地妇女乳汁的内源性大麻素代谢组特征分析
Curr Dev Nutr. 2019 Mar 27;3(6):nzz018. doi: 10.1093/cdn/nzz018. eCollection 2019 Jun.
10
Transgenerational cycle of obesity and diabetes: investigating possible metabolic precursors in cord blood from the PREOBE study.代际肥胖和糖尿病周期：PREOBE 研究中脐带血中可能的代谢前体研究。
Acta Diabetol. 2019 Sep;56(9):1073-1082. doi: 10.1007/s00592-019-01349-y. Epub 2019 May 6.

代谢组学可以为围产期营养提供新的见解。

Metabolomics can provide new insights into perinatal nutrition.

机构信息

Neonatal Intensive Care Unit, AOU Cagliari Department of Surgery, University of Cagliari, Cagliari, Italy.

出版信息

Acta Paediatr. 2023 Feb;112(2):233-241. doi: 10.1111/apa.16096. Epub 2021 Sep 13.

DOI:10.1111/apa.16096
PMID:34487568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10078676/
Abstract

Perinatal nutrition is a key factor related to the Developmental Origin of Health and Disease hypothesis, which states that each and every event that happens during the periconceptional period and pregnancy can affect the health status of an individual. Metabolomics can be a very useful tool for gathering information about the effect of perinatal nutrition on both mothers and newborn infants. This non-systematic review focuses on the main metabolites detected by this technique, with regard to gestational diabetes, intrauterine growth restriction and breast milk. Conclusion. Nutrition, metabolome and microbiome interactions are gaining interest in the scientific community.

摘要

围产期营养是与健康和疾病的发育起源假说相关的关键因素，该假说指出，围孕期和怀孕期间发生的每一个事件都可能影响个体的健康状况。代谢组学可以是一个非常有用的工具，用于收集关于围产期营养对母亲和新生儿影响的信息。本非系统性综述重点介绍了该技术检测到的主要代谢物，涉及妊娠期糖尿病、宫内生长受限和母乳。结论：营养、代谢组学和微生物组的相互作用正在引起科学界的兴趣。