Ahmed Salman, Hasan Muhammad Mohtasheemul, Aschner Michael, Mirzaei Hamed, Alam Waqas, Mukarram Shah Syed Muhammad, Khan Haroon
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10463, USA.
Cell Signal. 2021 Nov;87:110142. doi: 10.1016/j.cellsig.2021.110142. Epub 2021 Sep 4.
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth and accelerated intrusion of normal brain tissue along with a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detail molecular mechanisms.
多形性胶质母细胞瘤（GBM）是人类最常见的原发性恶性脑肿瘤。其特征是细胞过度生长，正常脑组织被加速侵入，且预后较差。目前的治疗标准，包括手术切除、放射治疗和化疗，大多无效，死亡率和复发率很高。因此，传统方法已发展为包括新的替代疗法，如天然化合物。水生物种提供了丰富的潜在药物来源。海洋肽在胶质母细胞瘤中的生理作用是通过一系列途径介导的，包括细胞凋亡、微管平衡紊乱、血管生成抑制、细胞迁移/侵袭和细胞活力；自噬和代谢酶下调。在此，我们阐述了海洋肽作为胶质母细胞瘤潜在安全治疗剂的疗效及其详细的分子机制。
