Ahmed Salman, Khan Haroon, Fakhri Sajad, Aschner Michael, Cheang Wai San
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan.
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Mol Cell Biochem. 2022 Feb;477(2):605-619. doi: 10.1007/s11010-021-04306-y. Epub 2021 Dec 2.
Cervical and ovarian cancers contribute significantly to female morbidity and mortality worldwide. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, offers poor outcomes. There are many side effects to traditional chemotherapeutic agents and treatment-resistant types, and often the immune response is depressed. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The potential anti-cancer peptides are less toxic to normal cells and can attenuate multiple drug resistance by providing an efficacious treatment approach. The physiological effects of marine peptides are described in this review focusing on various pathways, such as apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability. The review also highlights the potential role of marine peptides as safe and efficacious therapeutic agent for the treatment of cervical and ovarian cancers.
宫颈癌和卵巢癌在全球范围内对女性的发病率和死亡率有重大影响。当前的治疗标准，包括手术切除、放射治疗和化疗，效果不佳。传统化疗药物存在许多副作用且有耐药类型，而且免疫反应常常受到抑制。因此，传统方法已发展为包括新的替代疗法，如天然化合物。水生物种提供了丰富的潜在药物来源。潜在的抗癌肽对正常细胞毒性较小，并且通过提供有效的治疗方法可以减轻多重耐药性。本综述描述了海洋肽的生理作用，重点关注各种途径，如细胞凋亡、微管平衡紊乱、血管生成抑制、细胞迁移/侵袭和细胞活力。该综述还强调了海洋肽作为治疗宫颈癌和卵巢癌的安全有效治疗剂的潜在作用。
