Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan.
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Mar Drugs. 2022 Jul 22;20(8):466. doi: 10.3390/md20080466.
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.
前列腺癌（PCa）是男性癌症死亡的主要原因，其治疗通常与严重的不良反应相关。因此，需要新的治疗方法。在这种情况下，天然化合物因其抗 PCa 特性而被广泛探索。水生生物中含有许多潜在的药物。抗癌肽对正常细胞的毒性较小，并通过多种机制提供有效的治疗方法，包括改变细胞活力、凋亡、细胞迁移/侵袭、抑制血管生成和微管平衡紊乱。本综述阐明了海洋肽作为治疗前列腺癌的有效且安全的治疗剂。
