Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan.
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Environ Res. 2023 Jun 15;227:115771. doi: 10.1016/j.envres.2023.115771. Epub 2023 Mar 24.
Malignant melanoma is the most dangerous type of skin cancer. It is becoming more common globally and is increasingly resistant to treatment options. Despite extensive research into its pathophysiology, there are still no proven cures for metastatic melanoma. Unfortunately, current treatments are frequently ineffective and costly, and have several adverse effects. Natural substances have been extensively researched for their anti-MM capabilities. Chemoprevention and adjuvant therapy with natural products is an emerging strategy to prevent, cure or treat melanoma. Numerous prospective drugs are found in aquatic species, providing a plentiful supply of lead cytotoxic chemicals for cancer treatment. Anticancer peptides are less harmful to healthy cells and cure cancer through several different methods, such as altered cell viability, apoptosis, angiogenesis/metastasis suppression, microtubule balance disturbances and targeting lipid composition of the cancer cell membrane. This review addresses marine peptides as effective and safe treatments for MM and details their molecular mechanisms of action.
恶性黑色素瘤是最危险的皮肤癌类型。它在全球范围内变得越来越普遍，并且对治疗选择的抵抗力越来越强。尽管对其病理生理学进行了广泛的研究，但对于转移性黑色素瘤仍然没有经过证实的治愈方法。不幸的是，目前的治疗方法通常无效且昂贵，并且具有多种不良反应。天然物质因其抗-MM 能力而被广泛研究。天然产物的化学预防和辅助治疗是预防、治愈或治疗黑色素瘤的新兴策略。水生物种中发现了许多有前途的药物，为癌症治疗提供了大量的细胞毒性化学物质。抗癌肽对健康细胞的危害较小，通过多种不同的方法治疗癌症，例如改变细胞活力、凋亡、血管生成/转移抑制、微管平衡紊乱和靶向癌细胞膜的脂质组成。这篇综述讨论了海洋肽作为 MM 的有效和安全治疗方法，并详细介绍了它们的作用机制。
