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变革澳大利亚的疫苗供应链:机遇与挑战。

Transforming the vaccine supply chain in Australia: Opportunities and challenges.

作者信息

Bozorgi Ali, Fahimnia Behnam

机构信息

Institute of Transport and Logistics Studies, The University of Sydney Business School, Sydney, Australia.

出版信息

Vaccine. 2021 Oct 1;39(41):6157-6165. doi: 10.1016/j.vaccine.2021.08.033. Epub 2021 Sep 4.

Abstract

BACKGROUND

Analyzing potential benefits of thermostable vaccines delivered through Micro Array Patch (MAP) has received great attention in low and middle-income countries. The experience may or may not be the same in developed countries where the infrastructure is more developed. It is anticipated that transforming the vaccine supply chain from syringe-and-needle to thermostable MAP-delivered vaccines will result in reduced supply chain costs - including manufacturing/supply, logistics/distribution, and administration costs - as well as reduced wastes and improved safety. This paper provides an end-to-end supply chain analysis comparing the key aspects (cost, safety and environmental aspects) of the conventional syringe-and-needle vaccine supply chain with those of the MAP vaccine supply chain for influenza vaccine delivery in Australia. Directions for future research in this area will be provided.

OBJECTIVE

To determine the potential supply chain impacts of replacing syringe-and-needle flu vaccine with MAP-enabled thermostable flu vaccine in Australia.

METHODS

We analyze the current flu vaccine supply chain in Australia to identify practical limitations and opportunities for improvement. Data/information is collected through interviewing the key stakeholders across vaccine supply chain including vaccine manufacturers, logistics providers, clinics, hospitals, and pharmacies.

FINDINGS

A detailed practice-informed analysis is completed on the key operations of the flu vaccine supply chain. Barriers and limitations of the conventional flu vaccine are discussed, along with potential improvements that can be achieved through the implementation of MAP-enabled flu vaccine delivery. We discuss how technology-driven innovations can help advance vaccine supply chains, improve vaccine visibility, reduce wastes, and enable informed decision-making.

CONCLUSION

We find that the benefits of moving from syringe-and-needle vaccines to thermostable MAP-delivered vaccines are beyond transportation and storage cost saving. Potential benefits through cost saving, waste reduction, and service level improvement are discussed along with various safety and wellbeing consequences followed by directions for future research in this area.

摘要

背景

分析通过微阵列贴片(MAP)提供的热稳定疫苗的潜在益处,在低收入和中等收入国家受到了极大关注。在基础设施更为发达的发达国家,这种经验可能相同,也可能不同。预计将疫苗供应链从注射器和针头模式转变为热稳定的MAP递送疫苗,将降低供应链成本,包括生产/供应、物流/分销和管理成本,同时减少浪费并提高安全性。本文提供了一个端到端的供应链分析,比较了澳大利亚常规注射器和针头流感疫苗供应链与MAP疫苗供应链在关键方面(成本、安全和环境方面)的情况。并将提供该领域未来研究的方向。

目的

确定在澳大利亚用MAP启用的热稳定流感疫苗替代注射器和针头流感疫苗对供应链的潜在影响。

方法

我们分析了澳大利亚当前的流感疫苗供应链,以确定实际限制和改进机会。通过采访疫苗供应链中的关键利益相关者,包括疫苗制造商、物流供应商、诊所、医院和药店,收集数据/信息。

结果

对流感疫苗供应链的关键操作进行了详细的基于实践的分析。讨论了传统流感疫苗的障碍和限制,以及通过实施MAP启用的流感疫苗递送可实现的潜在改进。我们讨论了技术驱动的创新如何有助于推动疫苗供应链发展、提高疫苗可见性、减少浪费并实现明智的决策。

结论

我们发现,从注射器和针头疫苗转向热稳定的MAP递送疫苗的好处不仅仅在于节省运输和存储成本。还讨论了通过节省成本、减少浪费和提高服务水平带来的潜在好处,以及各种安全和健康后果,随后给出了该领域未来研究的方向。

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