Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Nat Commun. 2021 Sep 6;12(1):5290. doi: 10.1038/s41467-021-25595-3.
Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.
小胶质细胞是具有多种功能的大脑驻留免疫细胞。然而，人们对小胶质细胞-血管相互作用知之甚少。在最近发表在《自然通讯》上的一篇论文中，Bisht 等人确定了一种信号机制，该机制可将小胶质细胞吸引并维持在毛细血管壁上。此外，他们还表明，小胶质细胞调节毛细血管血管张力，在调节血流方面发挥的作用比之前认为的更为重要。
