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Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global.

作者信息

Rings Thorsten, von Wrede Randi, Bröhl Timo, Schach Sophia, Helmstaedter Christoph, Lehnertz Klaus

机构信息

Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany.

Helmholtz Institute for Radiation and Nuclear Physics, University of Bonn, Bonn, Germany.

出版信息

Front Physiol. 2021 Aug 20;12:700261. doi: 10.3389/fphys.2021.700261. eCollection 2021.


DOI:10.3389/fphys.2021.700261
PMID:34489724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8417898/
Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain stimulation technique considered as a potential supplementary treatment option for a wide range of diseases. Although first promising findings were obtained so far, the exact mode of action of taVNS is not fully understood yet. We recently developed an examination schedule to probe for immediate taVNS-induced modifications of large-scale epileptic brain networks. With this schedule, we observed short-term taVNS to have a topology-modifying, robustness- and stability-enhancing immediate effect on large-scale functional brain networks from subjects with focal epilepsies. We here expand on this study and investigate the impact of short-term taVNS on various local and global characteristics of large-scale evolving functional brain networks from a group of 30 subjects with and without central nervous system diseases. Our findings point to differential, at first glance counterintuitive, taVNS-mediated alterations of local and global topological network characteristics that result in a reconfiguration of networks and a modification of their stability and robustness properties. We propose a model of a stimulation-related stretching and compression of evolving functional brain networks that may help to better understand the mode of action of taVNS.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/d2d38a921f35/fphys-12-700261-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/6d15891c7fc5/fphys-12-700261-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/d9a9e1c34b58/fphys-12-700261-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/5b1d03d25fce/fphys-12-700261-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/d2d38a921f35/fphys-12-700261-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/6d15891c7fc5/fphys-12-700261-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/d9a9e1c34b58/fphys-12-700261-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/5b1d03d25fce/fphys-12-700261-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/8417898/d2d38a921f35/fphys-12-700261-g0004.jpg

相似文献

[1]
Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global.

Front Physiol. 2021-8-20

[2]
Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy.

Sci Rep. 2021-4-12

[3]
Transcutaneous Auricular Vagus Nerve Stimulation Differently Modifies Functional Brain Networks of Subjects With Different Epilepsy Types.

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[4]
Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day.

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[5]
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Brain Sci. 2024-9-21

[6]
Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression.

J Neuroinflammation. 2020-2-12

[7]
Effects of transcutaneous auricular vagus nerve stimulation and exploration of brain network mechanisms in children with high-functioning autism spectrum disorder: study protocol for a randomized controlled trial.

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[8]
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[9]
Immediate modulatory effects of transcutaneous auricular vagus nerve stimulation on the resting state of major depressive disorder.

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[10]
Phasic, Event-Related Transcutaneous Auricular Vagus Nerve Stimulation Modifies Behavioral, Pupillary, and Low-Frequency Oscillatory Power Responses.

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引用本文的文献

[1]
Stable Yet Destabilised: Towards Understanding Brain Network Dynamics in Psychogenic Disorders.

J Clin Med. 2025-1-21

[2]
Evidence of bottom-up homeostatic modulation induced taVNS during emotional and Go/No-Go tasks.

Exp Brain Res. 2024-9

[3]
Investigating neuromodulatory effect of transauricular vagus nerve stimulation on resting-state electroencephalography.

Biomed Eng Lett. 2024-2-24

[4]
The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.

Front Netw Physiol. 2024-1-16

[5]
Modifying functional brain networks in focal epilepsy by manual visceral-osteopathic stimulation of the vagus nerve at the abdomen.

Front Netw Physiol. 2023-7-13

[6]
Synergistic effects of transcutaneous vagus nerve stimulation and inhibitory control training on electrophysiological performance in healthy adults.

Front Neurosci. 2023-3-9

[7]
Perspectives on Understanding Aberrant Brain Networks in Epilepsy.

Front Netw Physiol. 2022-4-5

[8]
Transcutaneous Auricular Vagus Nerve Stimulation Differently Modifies Functional Brain Networks of Subjects With Different Epilepsy Types.

Front Hum Neurosci. 2022-6-23

[9]
Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day.

Brain Sci. 2022-4-26

[10]
Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner.

Front Neurosci. 2022-3-3

本文引用的文献

[1]
Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness.

Sci Rep. 2022-7-8

[2]
Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy.

Sci Rep. 2021-4-12

[3]
Brain Functional Mechanisms Determining the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Primary Insomnia.

Front Neurosci. 2021-3-12

[4]
Tinnitus treatment by vagus nerve stimulation: A systematic review.

PLoS One. 2021

[5]
Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application.

Neurosci Bull. 2021-6

[6]
Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities.

Sci Rep. 2020-12-14

[7]
Transcutaneous Auricular Vagal Nerve Stimulation and Disorders of Consciousness: A Hypothesis for Mechanisms of Action.

Front Neurol. 2020-8-25

[8]
Identifying edges that facilitate the generation of extreme events in networked dynamical systems.

Chaos. 2020-7

[9]
Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice.

Front Neurosci. 2020-4-28

[10]
A literature review on the neurophysiological underpinnings and cognitive effects of transcutaneous vagus nerve stimulation: challenges and future directions.

J Neurophysiol. 2020-5-1

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