Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Shengjing Hospital, China Medical University, Shenyang, China.
Front Public Health. 2021 Aug 20;9:706524. doi: 10.3389/fpubh.2021.706524. eCollection 2021.
Peak expiratory flow (PEF), as an essential index used for screening and monitoring asthma, chronic obstructive pulmonary disease, and respiratory mortality especially in the elderly, is recommended for low-resource settings in low- and middle-income countries. However, few studies have focused on the reference of PEF in China, especially in middle-aged and elderly people. Thus, this study aimed to determine age- and sex-specific reference values of PEF in the middle-aged and elderly Chinese population. There were 8,914 participants who were included for risk factor analysis and 5,498 participants included for reference value analysis. The PEF was measured using a peak flow meter in liters per minute. The distributions of standardized PEF terciles stratified by sex and age were reported. Multiple linear regression analysis was used to determine the associations between risk factors and PEF. The PEF was higher in men than women across all age subgroups. The value of PEF decreased with age in both men and women. Height, weight, handgrip strength, and residence in rural were positively associated with PEF. Age and smoking status were negatively associated with PEF significantly in both men and women ( < 0.05). The mean PEF values were 367.10 and 253.00 L/min for men and women, respectively. Meanwhile, the prevalence of low PEF was 3.94 and 3.32% for men and women, respectively. Age- and sex-specific centiles of standardized PEF for the middle-aged and elderly Chinese population were estimated. The reference values for low PEF could provide reference standards for epidemiological studies and clinical practices in the future. Interventions to improve lung functions or to prevent respiratory disease should be paid more attention to factors associated with PEF.
峰流速（PEF）作为筛选和监测哮喘、慢性阻塞性肺疾病和尤其是老年人呼吸性死亡的重要指标，建议在中低收入国家的资源匮乏地区使用。然而，很少有研究关注中国的 PEF 参考值，特别是在中老年人中。因此，本研究旨在确定中国中老年人 PEF 的年龄和性别特异性参考值。共有 8914 名参与者纳入危险因素分析，5498 名参与者纳入参考值分析。PEF 使用峰值流量计以升/分钟为单位进行测量。报告了按性别和年龄分层的标准化 PEF 三分位数的分布。使用多元线性回归分析确定危险因素与 PEF 之间的关联。PEF 在所有年龄组中男性均高于女性。PEF 随年龄增长在男性和女性中均呈下降趋势。身高、体重、握力和农村居住与 PEF 呈正相关。年龄和吸烟状况与男女的 PEF 显著负相关（<0.05）。男性和女性的平均 PEF 值分别为 367.10 和 253.00 L/min。同时，男性和女性低 PEF 的患病率分别为 3.94%和 3.32%。本研究为中国中老年人制定了年龄和性别特异性的标准化 PEF 百分位数。低 PEF 的参考值可为未来的流行病学研究和临床实践提供参考标准。应更加关注与 PEF 相关的因素，以改善肺功能或预防呼吸疾病。
