Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Medical School Southeast University, Nanjing, China.
Curr Med Res Opin. 2020 Apr;36(4):667-675. doi: 10.1080/03007995.2020.1722082. Epub 2020 Feb 8.
Asthma-COPD overlap (ACO) is a persistent airflow limitation with features of both asthma and chronic obstructive pulmonary disease (COPD). No studies have explored the prevalence of ACO at the national level in China. In this study, we aimed to estimate the prevalence of ACO and to assess the associated factors and comorbidities of ACO in middle-aged and older Chinese. Participants aged 45 years and over in a nationally representative investigation - the China Health and Retirement Longitudinal Study (CHARLS) in 2011 - were included. ACO was defined as a dual self-reported physician diagnosis of asthma and COPD. The prevalence of ACO was demonstrated across different characteristic groups. The potentially associated factors and comorbidities were examined by logistic regressions. The prevalence of ACO was 2.22% in general middle-aged and older Chinese. The relative prevalence of ACO to asthma was 62.53% and that to COPD was 21.99%. Older age (≥70 years), Northwest China residence, smoking (former and current) and former alcohol drinking were associated with a higher risk of ACO. Comorbidities of ACO included stomach or other digestive disease, kidney disease, cardiovascular disease, and arthritis or rheumatism. ACO was a prevalent condition in middle-aged and older Chinese. Better management and more research on ACO are needed.
哮喘-慢阻肺重叠（ACO）是一种持续性气流受限，同时具有哮喘和慢性阻塞性肺疾病（COPD）的特征。目前尚无研究探讨中国全国范围内 ACO 的患病率。本研究旨在估计 ACO 的患病率，并评估中国中老年人 ACO 的相关因素和合并症。纳入了在具有全国代表性的调查-中国健康与退休纵向研究（CHARLS）中年龄在 45 岁及以上的参与者。ACO 定义为哮喘和 COPD 的双重自我报告的医生诊断。在不同特征组中展示了 ACO 的患病率。通过逻辑回归检查了潜在的相关因素和合并症。在一般的中老年中国人中，ACO 的患病率为 2.22%。ACO 相对于哮喘的相对患病率为 62.53%，相对于 COPD 的相对患病率为 21.99%。年龄较大（≥70 岁）、居住在中国西北部、吸烟（曾经和现在）和曾经饮酒与 ACO 的风险增加相关。ACO 的合并症包括胃或其他消化系统疾病、肾脏疾病、心血管疾病和关节炎或风湿病。ACO 在中老年中国人中是一种普遍存在的疾病。需要更好地管理和对 ACO 进行更多的研究。
