Univ. Lille, Institut Pasteur de Lille, INSERM U1167 - RID-AGE Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France; CHU Lille, Epidemiology Service, Health Economics and Prevention, F-59000 Lille, France.
Univ. Lille, EA4483 - IMPECS (IMPact of Environmental ChemicalS on human health), F-59000 Lille, France.
Environ Res. 2018 Jul;164:140-148. doi: 10.1016/j.envres.2018.02.016. Epub 2018 Feb 24.
The objective of the present study was to investigate the relationship between sources of household air pollution, respiratory symptoms and lung function.
3039 adults aged from 40 to 65 participated in the 2011-2013 ELISABET cross-sectional survey in northern France. Lung function was measured using spirometry. During a structured interview, respiratory symptoms, household fuels, exposure to moulds, and use of ventilation were recorded on a questionnaire.
The self-reported presence of mould in at least two rooms (not including the bathroom and the kitchen) was associated with a 2.5% lower predicted forced expiratory volume in 1 s (95% confidence interval, -4.7 to -0.29; p-trend <0.05) and a higher risk of wheezing (p-trend < 0.001). Visible condensation was associated with wheezing (p < .05) and chronic cough (p < .05). There were no significant associations with the type of household fuel or inadequate ventilation/aeration. Similar results were found when the analyses were restricted to participants without known respiratory disease.
Our results suggest that the presence of mould (known to be associated with more severe asthma symptoms) could also have an impact on respiratory symptoms and lung function in the general population and in populations without known respiratory disease.
本研究旨在探讨家庭空气污染来源与呼吸症状和肺功能之间的关系。
2011 年至 2013 年，3039 名年龄在 40 至 65 岁之间的成年人参加了法国北部的 2011-2013 年 ELISABET 横断面调查。使用肺活量计测量肺功能。在一项结构化访谈中，通过问卷记录呼吸症状、家庭燃料、接触霉菌和通风使用情况。
报告至少两间房间（不包括浴室和厨房）存在霉菌与预计用力呼气量降低 2.5%（95%置信区间为-4.7 至-0.29；趋势 p 值<0.05）和喘息风险增加（趋势 p 值<0.001）相关。可见冷凝与喘息（p<0.05）和慢性咳嗽（p<0.05）相关。与家用燃料类型或通风不足/通气不良没有显著关联。当分析仅限于无已知呼吸道疾病的参与者时，也得到了类似的结果。
我们的研究结果表明，霉菌的存在（已知与更严重的哮喘症状有关）也可能对普通人群和无已知呼吸道疾病人群的呼吸症状和肺功能产生影响。
