面向可穿戴设备的连续血糖监测生物传感器的进展
Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables.
作者信息
Johnston Lucy, Wang Gonglei, Hu Kunhui, Qian Chungen, Liu Guozhen
机构信息
School of Engineering, The University of Glasgow, Glasgow, United Kingdom.
School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China.
出版信息
Front Bioeng Biotechnol. 2021 Aug 19;9:733810. doi: 10.3389/fbioe.2021.733810. eCollection 2021.
Continuous glucose monitors (CGMs) for the non-invasive monitoring of diabetes are constantly being developed and improved. Although there are multiple biosensing platforms for monitoring glucose available on the market, there is still a strong need to enhance their precision, repeatability, wearability, and accessibility to end-users. Biosensing technologies are being increasingly explored that use different bodily fluids such as sweat and tear fluid, etc., that can be calibrated to and therefore used to measure blood glucose concentrations accurately. To improve the wearability of these devices, exploring different fluids as testing mediums is essential and opens the door to various implants and wearables that in turn have the potential to be less inhibiting to the wearer. Recent developments have surfaced in the form of contact lenses or mouthguards for instance. Challenges still present themselves in the form of sensitivity, especially at very high or low glucose concentrations, which is critical for a diabetic person to monitor. This review summarises advances in wearable glucose biosensors over the past 5 years, comparing the different types as well as the fluid they use to detect glucose, including the CGMs currently available on the market. Perspectives on the development of wearables for glucose biosensing are discussed.
用于糖尿病无创监测的连续血糖监测仪(CGM)正在不断研发和改进。尽管市场上有多种用于监测血糖的生物传感平台,但仍迫切需要提高其精度、重复性、可穿戴性以及终端用户的可及性。人们越来越多地探索生物传感技术,这些技术使用不同的体液,如汗液和泪液等,这些体液可以进行校准,从而用于准确测量血糖浓度。为了提高这些设备的可穿戴性,探索不同的流体作为测试介质至关重要,这为各种植入式和可穿戴设备打开了大门,而这些设备反过来有可能对佩戴者的限制更小。例如,最近出现了隐形眼镜或护齿等形式的进展。挑战仍然以灵敏度的形式存在,特别是在非常高或非常低的葡萄糖浓度下,这对糖尿病患者进行监测至关重要。本综述总结了过去5年可穿戴葡萄糖生物传感器的进展,比较了不同类型以及它们用于检测葡萄糖的流体,包括目前市场上可用的CGM。还讨论了葡萄糖生物传感可穿戴设备的发展前景。
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