Wu Xue, Sun Meng, Yang Zhi, Lu Chenxi, Wang Qiang, Wang Haiying, Deng Chao, Liu Yonglin, Yang Yang
Department of Paediatrics, Shenmu Hospital, School of Life Sciences and Medicine, Northwest University, Shenmu, China.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.
Front Cell Dev Biol. 2021 Aug 19;9:686548. doi: 10.3389/fcell.2021.686548. eCollection 2021.
Chemokine is a structure-related protein with a relatively small molecular weight, which can target cells to chemotaxis and promote inflammatory response. Inflammation plays an important role in aging. C-C chemokine receptor 9 (CCR9) and its ligand C-C chemokine ligand 25 (CCL25) are involved in the regulating the occurrence and development of various diseases, which has become a research hotspot. Early research analysis of CCR9-deficient mouse models also confirmed various physiological functions of this chemokine in inflammatory responses. Moreover, CCR9/CCL25 has been shown to play an important role in a variety of inflammation-related diseases, such as cardiovascular disease (CVD), rheumatoid arthritis, hepatitis, inflammatory bowel disease, asthma, etc. Therefore, the purpose of this review gives an overview of the recent advances in understanding the roles of CCR9/CCL25 in inflammation and inflammation-associated diseases, which will contribute to the design of future experimental studies on the potential of CCR9/CCL25 and advance the research of CCR9/CCL25 as pharmacological inflammatory targets.
趋化因子是一种分子量相对较小的结构相关蛋白，它可使靶细胞产生趋化作用并促进炎症反应。炎症在衰老过程中起着重要作用。C-C趋化因子受体9（CCR9）及其配体C-C趋化因子配体25（CCL25）参与多种疾病的发生和发展调控，已成为研究热点。对CCR9基因缺陷小鼠模型的早期研究分析也证实了这种趋化因子在炎症反应中的多种生理功能。此外，CCR9/CCL25已被证明在多种炎症相关疾病中起重要作用，如心血管疾病（CVD）、类风湿性关节炎、肝炎、炎症性肠病、哮喘等。因此，本综述旨在概述CCR9/CCL25在炎症及炎症相关疾病中作用的最新研究进展，这将有助于设计未来关于CCR9/CCL25潜力的实验研究，并推动CCR9/CCL25作为药理学炎症靶点的研究。
