Yu Yi, Cui Chen, Guan Shu Yuan, Xu Ruo Shi, Zheng Li Wei, Zhou Xue Dong, Fan Yi
Chin J Dent Res. 2021 Sep 7;24(3):143-152. doi: 10.3290/j.cjdr.b1965049.
Tooth eruption is closely linked to the normal development of dentition and proper establishment of occlusion. Disturbances in tooth eruption may affect oral physiological functions, facial contour and aesthetics; it is therefore important to understand the eruption process. This process is a complex biological event involving dynamic changes at the tissue and cellular levels. It is guided by anatomical structures as well as biological and molecular factors that result in the movement of the tooth to its final functional position in the oral cavity. Evidence increasingly suggests that stem cells contribute to tooth development and eruption. Multiple stem cell populations have been discovered in teeth and in their supporting tissues, such as dental follicle precursor cells, orofacial bone-/bone marrow-derived mesenchymal stem cells, periodontal ligament stem cells, stem cells from the apical papilla and dental pulp stem cells. These stem cells exhibit distinct differentiation capacities and are closely linked to alveolar bone remodelling, periodontium development and root formation during the eruption process. The present review summarises the current knowledge of the characteristics and functions of orofacial stem cells in tooth eruption, with a particular focus on recent discoveries concerning their lineage allocation and regulatory mechanisms.
牙齿萌出与牙列的正常发育以及咬合关系的正确建立密切相关。牙齿萌出障碍可能会影响口腔生理功能、面部轮廓和美观；因此，了解萌出过程很重要。这个过程是一个复杂的生物学事件，涉及组织和细胞水平的动态变化。它受解剖结构以及生物和分子因素的引导，这些因素导致牙齿移动到口腔中的最终功能位置。越来越多的证据表明，干细胞有助于牙齿发育和萌出。在牙齿及其支持组织中发现了多个干细胞群体，如牙囊前体细胞、口腔颌面部骨/骨髓来源的间充质干细胞、牙周膜干细胞、根尖乳头干细胞和牙髓干细胞。这些干细胞表现出不同的分化能力，并且在萌出过程中与牙槽骨重塑、牙周组织发育和牙根形成密切相关。本综述总结了目前关于口腔颌面部干细胞在牙齿萌出中的特征和功能的知识，特别关注了有关它们的谱系分配和调控机制的最新发现。
