J Drugs Dermatol. 2021 Sep 1;20(9):932-938. doi: 10.36849/jdd.6312.
Genetic and environmental factors influence stratum corneum (SC) barrier properties and function. Researchers increasingly focus on biophysical studies that may help clinicians provide their patients with an informed choice on tailormade skincare. This literature review on skin barrier properties comparing different ethnic populations aims to offer insights into the information's clinical relevance.
A literature review followed by panel discussions and an online review process aimed to answer the questions: Are there racial/ethnic differences in the SC barrier structure and healthy skin barrier function? Is there a need for specific cleansers and moisturizers?
Ethnic categories based on race and ethnicity are often not well defined and inconsistent across different studies. Studies comparing ethnic groups' physical and biochemical skin barrier properties have reported differences in transepidermal water loss (TEWL), skin lipid levels, pH, and mast cell granule size. However, these studies frequently had methodological flaws, mainly were small, and demonstrated conflicting results. The literature suggests racial/ethnic variations in ceramide content, SC structure, and filaggrin mutations. Furthermore, studies have shown a greater burden of pruritus and atopic dermatitis among Black populations. Data on barrier properties in Hispanic/LatinX and South Asian populations are lacking.
Robust comparative studies are needed to understand these basic concepts to help tailor skincare and skin of color patients' education. J Drugs Dermatol. 2021;20(9):932-938. doi:10.36849/JDD.6312.
遗传和环境因素影响角质层（SC）屏障特性和功能。研究人员越来越关注生物物理研究，这可能有助于临床医生为患者提供有关定制护肤品的明智选择。本文对不同种族人群的皮肤屏障特性进行了文献综述，旨在提供有关该信息临床相关性的见解。
文献综述，随后进行小组讨论和在线审查过程，旨在回答以下问题：SC 屏障结构和健康皮肤屏障功能是否存在种族/民族差异？是否需要特定的清洁剂和保湿剂？
基于种族和民族的种族类别通常定义不明确，并且在不同的研究中不一致。比较不同种族群体的物理和生化皮肤屏障特性的研究报告了经皮水分流失（TEWL）、皮肤脂质水平、pH 值和肥大细胞颗粒大小的差异。然而，这些研究经常存在方法学缺陷，主要是规模较小，并且结果相互矛盾。文献表明角质层含量、SC 结构和丝聚合蛋白突变存在种族/民族差异。此外，研究表明黑人群体中瘙痒和特应性皮炎的负担更大。缺乏西班牙裔/拉丁裔和南亚人群的屏障特性数据。
需要进行强有力的比较研究来了解这些基本概念，以帮助定制护肤品和有色人种患者的教育。J 皮肤病学杂志。2021;20(9):932-938。doi:10.36849/JDD.6312.
