Key Laboratory of Environment and Human Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Department of Environmental Toxicology, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Environ Sci Technol. 2022 Jun 7;56(11):7185-7193. doi: 10.1021/acs.est.1c03146. Epub 2021 Sep 7.
We conducted a crossover study employing air cleaner intervention among 125 schoolchildren aged 9-12 years in a boarding school in Beijing, China. The PM concentrations were monitored, and 27 biomarkers were analyzed. We used the linear mixed-effects model to evaluate the association of intervention/time-weighted PM concentrations with biomarkers. The outcomes showed that air cleaner intervention was associated with FeNO, exhaled breath condensate (EBC) IL-1β, and IL-6, which decreased by 12.57%, 10.83%, and 4.33%, respectively. Similar results were observed in the associations with PMs. Lag 1 day PMs had the strongest relationship with biomarkers, and significant changes were observed in biomarkers such as FEV, FeNO, EBC 8-iso, and MCP-1. Boys showed higher percentage changes than girls, and the related biomarkers were FeNO, EBC 4-HNE, IL-1β, IL-6, and MCP-1. The results showed that biomarkers such as FeNO, EBC IL-6, MCP-1, and 4-HNE could sensitively reflect the early abnormal response of the respiratory system under short-term PM exposure among healthy schoolchildren and indicated that (1) air cleaners exert a protective effect on children's respiratory system. (2) PM had lag and cumulative effect, lag 1 day had the greatest effect. (3) The boys were more sensitive than the girls.
我们在中国北京的一所寄宿学校中进行了一项采用空气清洁器干预的 125 名 9-12 岁学童的交叉研究。监测了 PM 浓度，并分析了 27 种生物标志物。我们使用线性混合效应模型评估干预/时间加权 PM 浓度与生物标志物的关联。结果表明，空气清洁器干预与 FeNO、呼出气冷凝液（EBC）中的 IL-1β和 IL-6 有关，其分别降低了 12.57%、10.83%和 4.33%。在与 PM 的关联中也观察到了类似的结果。滞后 1 天的 PM 与生物标志物的关系最强，在 FEV、FeNO、EBC 8-iso 和 MCP-1 等生物标志物中观察到了显著变化。男孩的变化百分比高于女孩，相关的生物标志物为 FeNO、EBC 4-HNE、IL-1β、IL-6 和 MCP-1。结果表明，FeNO、EBC IL-6、MCP-1 和 4-HNE 等生物标志物可以敏感地反映短期 PM 暴露对健康学童呼吸系统的早期异常反应，表明（1）空气清洁器对儿童的呼吸系统具有保护作用。（2）PM 具有滞后和累积效应，滞后 1 天的影响最大。（3）男孩比女孩更敏感。
