Giroux Élodie, Fayet Yohan, Serviant-Fine Thibaut
Faculté de philosophie, Université Jean Moulin Lyon 3, Palais de l'université, 15 quai Claude-Bernard, 69007 Lyon, France - Institut de recherches philosophiques de Lyon, EA 4187, Lyon, France - Laboratoire SPHere, UMR 7219, Paris, France.
Équipe Évaluation médicale et sarcomes (EMS), Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France - Département de sciences humaines et sociales, Centre Léon Bérard, 28 rue Laënnec 69373 Lyon Cedex 08, France - RESHAPE (Research on Healthcare Performance), Inserm U1290, Université Claude Bernard Lyon 1, Lyon, France.
Med Sci (Paris). 2021 Aug-Sep;37(8-9):774-778. doi: 10.1051/medsci/2021092. Epub 2021 Sep 7.
In a post-genomics context, the concept of the exposome was introduced by Christopher Wild to advance a unified approach of exposures and consolidate different disciplinary fields of environmental health research. The exposome approach is characterized by the will to develop an integrative, longitudinal and more precise analysis of exposures, through the identification of biomarkers. The application of this plastic concept constitutes a privileged field of exploration of current issues and tensions, notably between holism and reductionism. This article analyses this concept and the associated promises. Improving the integration of biological, environmental and social data, the exposome concept supports practical interactions in the field of environmental health research and the advent of novel crosswise concepts to understand aetiology, such as 'embodiment' or 'sociomarkers'.
在后基因组学背景下，克里斯托弗·怀尔德提出了暴露组的概念，以推进对暴露的统一研究方法，并整合环境卫生研究的不同学科领域。暴露组方法的特点是希望通过识别生物标志物，对暴露进行综合、纵向且更精确的分析。这一灵活概念的应用构成了探索当前问题和矛盾的一个特殊领域，尤其是在整体论和还原论之间。本文分析了这一概念及其相关前景。暴露组概念有助于改善生物、环境和社会数据的整合，支持环境卫生研究领域的实际互动，并催生了诸如“体现”或“社会标志物”等用于理解病因的新型交叉概念。
