Department of Cardiology - Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
DeBakey Heart and Vascular Center, Houston Methodist, Houston, TX, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Int J Hyg Environ Health. 2024 Jan;255:114290. doi: 10.1016/j.ijheh.2023.114290. Epub 2023 Nov 17.
In 2005, Christopher P. Wild introduced the exposome concept, encompassing the biochemical changes in the organism in response to the totality of all environmental exposures throughout the entire lifespan and their association with health outcomes. The exposome concept also aimed at to completing the genome, that describes the genetic predisposition as a determinant of disease and death as well as potential targets of intervention. The exposome can be subdivided into multiple pollutomes related to specific chemical and physical pollutants (or other forms of environmental risks), periods of life (infancy, childhood, adolescence, adulthood, and old age) or geographical locations. While exposome research and, in general, health research of the last decades has predominantly focused on what factors contribute to and initiate morbidity and mortality, little is done on factors that will help to develop, maintain, or even increase human health. We want to contribute to this reorientation by supporting and implementing the beneficial exposome, comprising all environmental exposures with the potential to promote health.
2005 年，克里斯托弗·P·怀尔德（Christopher P. Wild）提出了暴露组学的概念，该概念涵盖了生物体对整个生命周期中所有环境暴露的整体反应的生化变化及其与健康结果的关联。暴露组学概念还旨在完成基因组，描述遗传易感性作为疾病和死亡的决定因素，以及干预的潜在靶点。暴露组可以细分为与特定化学和物理污染物（或其他形式的环境风险）、生命阶段（婴儿期、儿童期、青春期、成年期和老年期）或地理位置相关的多个污染物组。虽然暴露组学研究，以及一般来说，过去几十年的健康研究主要集中在哪些因素导致发病率和死亡率，以及对有助于发展、维持甚至提高人类健康的因素研究甚少。我们希望通过支持和实施有益的暴露组学来促进这一重新定位，该暴露组学包括所有具有促进健康潜力的环境暴露。
