非甾体抗炎药的使用与帕金森病发病无关：一项挪威处方数据库研究。
NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
机构信息
Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
出版信息
PLoS One. 2021 Sep 7;16(9):e0256602. doi: 10.1371/journal.pone.0256602. eCollection 2021.
OBJECTIVE
Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson's disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID use is associated with a lower incidence of PD.
METHODS
We compared the incidence of PD among users of NSAIDs in a population-based retrospective study using the Norwegian Prescription Database from 2004 to 2017. In total 7580 PD patients were identified using dopaminergic therapy over time as proxy for PD diagnosis. Analyses were performed with minimum 90 and 365 defined daily dose (DDD) NSAID exposure, respectively. Time-dependent Cox regression model and a binary logistic regression analysis with a 5-year lag until PD diagnosis were performed for all NSAIDs.
RESULTS
There was overall no decrease in incidence of PD among NSAID users compared to controls. Using a minimum of 90 or 365 DDD threshold of exposure produced similar results. Analysis of individual NSAIDs did not show difference in PD incidence compared to controls Age-specific incidence rates of PD were comparable to reported age-specific incidence rates in previous studies.
INTERPRETATION
Our findings provide no evidence that cumulative high exposure to NSAIDs affects the risk of developing PD.
目的
非甾体抗炎药（NSAIDs）的使用是否降低帕金森病（PD）的发病风险仍未解决。在这里，我们利用挪威处方数据库来研究 NSAID 的使用是否与较低的 PD 发病率相关。
方法
我们在一项基于人群的回顾性研究中，利用挪威处方数据库（2004 年至 2017 年），比较了 NSAID 使用者的 PD 发病率。共通过多巴胺能治疗的时间来确定 7580 名 PD 患者作为 PD 诊断的替代指标。使用最小 90 和 365 日定义剂量（DDD）的 NSAID 暴露分别进行了时间依赖性 Cox 回归模型和 5 年滞后至 PD 诊断的二元逻辑回归分析。
结果
与对照组相比，NSAID 使用者的 PD 发病率总体上没有降低。使用最小 90 或 365 DDD 暴露阈值产生了类似的结果。与对照组相比，对个别 NSAID 的分析并未显示 PD 发病率的差异。与之前研究报告的年龄特异性 PD 发病率相比，特定年龄的 PD 发病率相当。
解释
我们的研究结果没有提供累积高剂量 NSAID 暴露会影响 PD 发病风险的证据。
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