Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy.
FISABIO Foundation, 46020, Valencia, Spain; Department of Health Sciences, European University of Valencia, 46023, Valencia, Spain.
Trends Cancer. 2021 Nov;7(11):978-981. doi: 10.1016/j.trecan.2021.08.006. Epub 2021 Sep 4.
Intratumor heterogeneity (ITH) develops in malignant tumors. Precision sampling that captures this tumor variability is essential for the implementation of precision oncology. We highlight the necessity to update current sampling protocols and implement a strategy to ensure ITH detection and characterization. A cost-effective strategy for such sampling has been modeled in clear cell renal cell carcinoma (CCRCC).
肿瘤内异质性（ITH）存在于恶性肿瘤中。精准采样以捕获这种肿瘤变异性对于实施精准肿瘤学至关重要。我们强调有必要更新当前的采样方案，并实施一项策略以确保 ITH 的检测和表征。在透明细胞肾细胞癌（CCRCC）中已经建立了一种经济有效的采样策略。
