肿瘤内异质性的汇聚观点。

Convergent insights into intratumor heterogeneity.

机构信息

Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy; Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy.

Department of Economic Analysis, University of the Basque Country (UPV/EHU), 48015 Bilbao, Spain; IKERBASQUE, Basque Foundation of Science, 48011 Bilbao, Spain.

出版信息

Trends Cancer. 2024 Jan;10(1):12-14. doi: 10.1016/j.trecan.2023.08.009. Epub 2023 Sep 6.

DOI:10.1016/j.trecan.2023.08.009

PMID:37684129

Abstract

Mathematics, conventional histology, and genomics converge to confirm that highly aggressive clear cell renal cell carcinomas (CCRCCs) display low levels of intratumor heterogeneity (ITH). We hypothesize that therapeutic strategies aimed at maintaining high ITH levels would be advisable to slow down cancer evolution and to improve survival.

摘要

数学、常规组织学和基因组学的结合证实，高度侵袭性的透明细胞肾细胞癌 (ccRCC) 显示出低水平的肿瘤内异质性 (ITH)。我们假设，旨在维持高 ITH 水平的治疗策略将是明智的，以减缓癌症的进化并提高生存率。