Department of Anesthesia (Ladha, Mistry, Wijeysundera, Hare, Mazer), St. Michael's Hospital, Unity Health Toronto and Institute of Health Policy, Management, and Evaluation (Ladha, Wijeysundera) and Institute of Medical Sciences (Mistry, Mazer) and Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network (Clarke) and Division of Cardiac Surgery (Verma), St. Michael's Hospital, Unity Health Toronto and Department of Surgery (Verma) and Department of Physiology (Hare, Mazer), University of Toronto, Toronto, Ont.
CMAJ. 2021 Sep 7;193(35):E1377-E1384. doi: 10.1503/cmaj.202392.
Cannabis use is increasing among young adults, but its effects on cardiovascular health are poorly understood. We aimed to assess the association between recent cannabis use and history of myocardial infarction (MI) in young adults (aged 18-44 yr).
We performed a cross-sectional study using pooled data from the 2017 and 2018 cohorts of the American Behavioral Risk Factor Surveillance System survey of US adults. We analyzed the association between any recent cannabis use and history of MI using a weighted logistic regression model that adjusted for demographic factors, socioeconomic factors, health-related behaviours, concomitant substance use and other comorbidities. We also assessed this association after stratifying by frequency of use and by primary method of consumption.
Among 33 173 young adults (18.5 million weighted), 4610 respondents (3.2 million weighted) reported recent cannabis use (17.5%, 95% confidence interval [CI] 16.8%-18.2%). A history of MI was more frequent among recent cannabis users ( = 61 of 4610, 1.3%) relative to nonusers ( = 240 of 28 563 [0.8%], adjusted odds ratio [OR] 2.07, 95% CI 1.12-3.82). A history of MI was associated with cannabis use of more than 4 times per month (adjusted OR 2.31, 95% CI 1.18-4.50), and with smoking as a primary method of consumption (adjusted OR 2.01, 95% CI 1.02-3.98).
Our study provides evidence supporting an association between recent cannabis use and history of MI in young adults. Increasing cannabis use in an at-risk population could have negative implications for cardiovascular health.
年轻人中使用大麻的现象正在增加，但人们对其对心血管健康的影响知之甚少。我们旨在评估年轻人（18-44 岁）近期大麻使用与心肌梗死（MI）病史之间的关系。
我们使用美国成年人 2017 年和 2018 年美国行为风险因素监测系统调查的汇总数据进行了一项横断面研究。我们使用加权逻辑回归模型分析了任何近期大麻使用与 MI 病史之间的关系，该模型调整了人口统计学因素、社会经济因素、与健康相关的行为、同时使用的物质和其他合并症。我们还按使用频率和主要消费方式对这种关联进行了分层评估。
在 33173 名年轻人（3317.3 万人）中，有 4610 名受访者（3201.4 万人）报告近期使用大麻（17.5%，95%置信区间[CI] 16.8%-18.2%）。与非使用者（28563 人中有 240 人[0.8%]）相比，近期大麻使用者（4610 人中有 61 人[1.3%]）更常患有 MI，调整后的比值比[OR]为 2.07，95%CI 为 1.12-3.82）。MI 病史与大麻使用超过每月 4 次有关（调整后的 OR 2.31，95%CI 1.18-4.50），与吸烟作为主要消费方式有关（调整后的 OR 2.01，95%CI 1.02-3.98）。
我们的研究提供了证据，支持年轻人近期大麻使用与 MI 病史之间的关联。在高危人群中，大麻使用的增加可能对心血管健康产生负面影响。
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