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泛癌症分析和单细胞分析揭示了 ABCC5 转运蛋白在肝细胞癌中的作用。

Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.

机构信息

Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, China.

Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.

出版信息

Channels (Austin). 2021 Dec;15(1):541-554. doi: 10.1080/19336950.2021.1968592.

DOI:10.1080/19336950.2021.1968592
PMID:34494510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8437464/
Abstract

Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer. Many patients with hepatocellular carcinoma are diagnosed at an advanced stage because the early symptoms are not obvious. For advanced hepatocellular carcinoma, immunotherapy and targeted therapy seem to be a promising direction. Finding a new prognostic marker for hepatocellular carcinoma and exploring its role in the immune microenvironment is of great value. ABCC transporters have previously been associated with drug resistance in hepatocellular tumors, but the exact mechanism remains unclear. Here, we conducted a study on ABCC5 in HCC and found that the expression of ABCC5 was up-regulated in HCC and was associated with poor prognosis. Further exploration revealed that ABCC5 was associated with immune infiltration of hepatocellular carcinoma. Single-cell analysis revealed a potential relationship between ABCC5 and immune cell differentiation. Therefore, it is significant to continue to explore the role of ABCC5 in hepatocellular carcinoma.

摘要

肝细胞癌（HCC）是最常见的肝癌亚型。许多肝细胞癌患者在晚期被诊断出来，因为早期症状不明显。对于晚期肝细胞癌，免疫治疗和靶向治疗似乎是一个有前途的方向。寻找肝细胞癌的新预后标志物并探索其在免疫微环境中的作用具有重要意义。ABCC 转运蛋白先前与肝细胞肿瘤的耐药性有关，但确切的机制尚不清楚。在这里，我们对 HCC 中的 ABCC5 进行了研究，发现 ABCC5 在 HCC 中的表达上调，并与不良预后相关。进一步的探索表明，ABCC5 与肝细胞癌的免疫浸润有关。单细胞分析揭示了 ABCC5 与免疫细胞分化之间的潜在关系。因此，继续探索 ABCC5 在肝细胞癌中的作用具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/fec72ed13b72/KCHL_A_1968592_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/9582de3a5af0/KCHL_A_1968592_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/52a24e07422a/KCHL_A_1968592_F0002_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/fe55c5326df6/KCHL_A_1968592_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/3afd55cce543/KCHL_A_1968592_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/ef889e88374b/KCHL_A_1968592_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/b8797b2e7c64/KCHL_A_1968592_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/fec72ed13b72/KCHL_A_1968592_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/9582de3a5af0/KCHL_A_1968592_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/52a24e07422a/KCHL_A_1968592_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/b49782bf01b1/KCHL_A_1968592_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/6f55a41b832d/KCHL_A_1968592_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/fe55c5326df6/KCHL_A_1968592_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/3afd55cce543/KCHL_A_1968592_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/ef889e88374b/KCHL_A_1968592_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/b8797b2e7c64/KCHL_A_1968592_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b71/8437464/fec72ed13b72/KCHL_A_1968592_F0009_OC.jpg

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