Chen Wen-Yi, Qian Yue, Chen Tian-Yun, Gu Xiao-Ping
Department of Anesthesiology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Aug;43(4):628-633. doi: 10.3881/j.issn.1000-503X.13146.
Neurodegenerative diseases are associated with neuroinflammation,oxidative stress,and aging,which can lead to cognitive and motor dysfunctions.Recent studies suggest that the development of neurodegenerative diseases is related to adaptive immunity,in which CD4T cells are involved as adaptive immune cells.Through different pathways,CD4T cells differentiate into effector and regulatory subsets,which may have different effects on the progression of neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,multiple sclerosis,and amyotrophic lateral sclerosis.Here,we review the role and research progress of CD4T cells in neurodegenerative diseases.
神经退行性疾病与神经炎症、氧化应激和衰老相关，这些因素可导致认知和运动功能障碍。最近的研究表明，神经退行性疾病的发展与适应性免疫有关，其中CD4T细胞作为适应性免疫细胞参与其中。通过不同途径，CD4T细胞分化为效应和调节亚群，这可能对阿尔茨海默病、帕金森病、多发性硬化症和肌萎缩侧索硬化症等神经退行性疾病的进展产生不同影响。在此，我们综述CD4T细胞在神经退行性疾病中的作用及研究进展。
