College of Animal Sciences & Technology, Northwest A & F University, China.
Department of Zoology, Shah Abdul Latif University, Khairpur, Sindh, Pakistan.
Comput Math Methods Med. 2022 Jan 17;2022:1636263. doi: 10.1155/2022/1636263. eCollection 2022.
The term "neurodegenerative disease" refers to a set of illnesses that primarily affect brain's neurons. Substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes Parkinson's disease (PD), a neurological disorder. PD leads to tremor, stiffness, impaired posture and balance, and loss of automatic movements. Patient with Parkinson's often develops a parkinsonian gait that includes a tendency to lean forward, small quick steps as if hurrying forward, and reduced swinging of the arms. They also may have trouble initiating or continuing movement. Gait analysis is often used to diagnose neurodegenerative illnesses and determine their stage. In this study, we attempt to investigate postural balance, and of gait signals for Parkinson's patients, also, we incorporate interim rehabilitation technique. We included 25 PD patients who had 2.5 to 3 IV score of Hoehn and Yahr scale. A ten-minute walk test has been performed to observe primary and secondary results of dual task interference on gait velocities, and gait time motion vector for right and left legs was observed. Two experimental ground conditions include three conditions of trunk alignment, that is, erect on a regular basis (RE), trunk dorsiflexion 30° (TF1), and trunk dorsiflexion 50° (TF2) were analysed. We identified the walking speed of PD patients was decreased, and trunk dorsiflexion variables influence the gait pattern of Parkinson's disease patients, where higher 95% CI for TF1 condition was reported. The regular erect trunk showed swing time reduction (0.7%) in PD, so the higher unified PD rating scale (UPDRS) values have significant difference in swing phase time in Parkinson's patients. The average Hoehn and Yahr scale (H&Y scale) was 4.3 ± 2.5 reported in the study participants. In a 10-week follow-up evaluation, the stance duration was shown to be substantial, as was the slower speed gait in the baseline condition. Excessive flexion was discovered in our investigation at the lower limb joints, particularly the knee and ankle. Patients with Parkinson's disease had similar maximum dorsiflexion and minimum plantarflexion values in stance. The trunk fraction conditions were found significant in patients after rehabilitation training. The best response to rehabilitation treatment was seen when the trunk was rotated. When steps and posture distribution analysis performed, we found that the trunk flexure 1 ( < 0.05), and trunk flexure 2 ( < 0.01) were shown significant values. When GRF threshold characteristics are employed, mean accuracy improves by 52%. Regardless of gait posture, the step regular trunk flexure had significantly higher posture than the corresponding level steps, with a considerable rise in the 50 in trunk dorsiflexion 2 gait relative to the step "L." This study shows that there was some significant improvement observed in the gait parameters among patients with PD's which shows positive impact of the intervention. Furthermore, rehabilitation programmes can aid and improve poor gait features in patients with Parkinson's disease, especially those who are in the early stages of the condition. This gait and balance research provides a rationale for intervention treatments, and their use in clinical practise enhances evidence of therapeutic efficacy. However, prolonged follow-up is needed to determine whether the advantages will remain all across disease's course, and future studies may recommend a specific rehabilitation technique based on gait analysis results.
“神经退行性疾病”一词是指一组主要影响大脑神经元的疾病。黑质(中脑多巴胺能核)缺乏称为多巴胺的激素会导致帕金森病(PD),这是一种神经系统疾病。PD 导致震颤、僵硬、姿势和平衡受损以及自动运动丧失。帕金森病患者通常会出现帕金森步态,包括向前倾斜的趋势、快速小步似乎急于向前、手臂摆动减少。他们也可能难以开始或继续运动。步态分析常用于诊断神经退行性疾病并确定其阶段。在这项研究中,我们试图研究帕金森病患者的姿势平衡和步态信号,并且我们结合了中期康复技术。我们纳入了 25 名 PD 患者,他们的 Hoehn 和 Yahr 量表评分为 2.5 至 3 分。进行了十分钟步行测试,以观察双重任务干扰对步态速度的主要和次要结果,以及观察右和左腿的步态时间运动向量。两个实验地面条件包括三种躯干对齐条件,即常规直立(RE)、躯干背屈 30°(TF1)和躯干背屈 50°(TF2)进行了分析。我们发现 PD 患者的行走速度下降,并且躯干背屈变量影响帕金森病患者的步态模式,其中 TF1 条件报告的 95%CI 更高。常规直立躯干在 PD 中显示摆动时间减少(0.7%),因此在帕金森病患者中,较高的统一帕金森病评定量表(UPDRS)值在摆动阶段时间上有显著差异。研究参与者的平均 Hoehn 和 Yahr 量表(H&Y 量表)为 4.3±2.5。在 10 周的随访评估中,基线条件下的站立持续时间较长,步态速度较慢。在我们的研究中发现下肢关节,尤其是膝盖和脚踝过度弯曲。帕金森病患者在站立时具有相似的最大背屈和最小跖屈值。躯干分数条件在康复训练后对患者有显著影响。当躯干旋转时,观察到对康复治疗的最佳反应。当进行步幅和姿势分布分析时,我们发现躯干弯曲 1(<0.05)和躯干弯曲 2(<0.01)显示出显著值。当采用 GRF 阈值特征时,平均准确率提高了 52%。无论步态姿势如何,常规躯干弯曲的步幅都明显高于相应水平的步幅,与“L”对应的步幅相比,50 处的躯干背屈 2 步态有了相当大的上升。这项研究表明,PD 患者的步态参数有一些显著改善,表明干预措施具有积极影响。此外,康复计划可以帮助和改善帕金森病患者的不良步态特征,特别是那些处于疾病早期的患者。这项步态和平衡研究为干预治疗提供了依据,其在临床实践中的应用增强了治疗效果的证据。然而,需要进行长期随访以确定这些优势是否会在整个疾病过程中持续存在,未来的研究可能会根据步态分析结果推荐特定的康复技术。