血清 asprosin 在不同多囊卵巢综合征亚型中的水平：一项横断面研究。

Serum asprosin level in different subtypes of polycystic ovary syndrome: a cross-sectional study.

机构信息

Shandong University, Center for Reproductive Medicine, Cheeloo College of Medicine - Jinan, China.

出版信息

Rev Assoc Med Bras (1992). 2021 Apr;67(4):590-596. doi: 10.1590/1806-9282.20201147.

DOI:10.1590/1806-9282.20201147

PMID:34495066

Abstract

OBJECTIVE

Polycystic ovary syndrome can be divided into different subtypes, including insulin resistance and hyperandrogenism. The aim of this study was to investigate the relationship between serum asprosin levels and polycystic ovary syndrome subtypes.

METHODS

A total of 93 women with polycystic ovary syndrome and 77 healthy women as controls were selected for this study. The clinical and laboratory data were compared between the Polycystic ovary syndrome group and the control group. The Polycystic ovary syndrome group was further divided into subgroups: (1) women with or without hyperandrogenism (polycystic ovary syndrome hyperandrogenism and Polycystic ovary syndrome none-hyperandrogenism, respectively) and (2) women with or without insulin resistance (polycystic ovary syndrome insulin resistance and Polycystic ovary syndrome none-insulin resistance, respectively). Serum asprosin was measured by using enenzyme-linked immunosorbent assay.

RESULTS

Serum asprosin levels showed no significant difference between the polycystic ovary syndrome and control groups. However, it was significantly lower in the Polycystic ovary syndrome HA and insulin resistance groups compared with the respective Polycystic ovary syndrome none-hyperandrogenism and none-insulin resistance groups (p<0.05). In the Polycystic ovary syndrome group, serum asprosin was negatively correlated with body mass index, luteinizing hormone, testosterone, basal antral follicles, fasting insulin, homeostatic model assessment of insulin resistance, and triglycerides. After adjusting for body mass index, the correlations were not significant, and asprosin was only positively correlated with prolactin (prolactin; r=0.426, p<0.001).

CONCLUSION

Our study shows that women with polycystic ovary syndrome hyperandrogenism or insulin resistance exhibit significantly lower serum asprosin levels compared with controls, and the lower asprosin level directly correlated with prolactin level.

摘要

目的

多囊卵巢综合征可分为不同亚型，包括胰岛素抵抗和高雄激素血症。本研究旨在探讨血清aspirin 水平与多囊卵巢综合征亚型的关系。

方法

本研究共纳入 93 例多囊卵巢综合征患者和 77 例健康对照者。比较多囊卵巢综合征组与对照组的临床和实验室资料。多囊卵巢综合征组进一步分为亚组：（1）高雄激素血症（多囊卵巢综合征高雄激素血症和多囊卵巢综合征无高雄激素血症）和（2）胰岛素抵抗（多囊卵巢综合征胰岛素抵抗和多囊卵巢综合征无胰岛素抵抗）。采用酶联免疫吸附法检测血清 asprosin 水平。

结果

多囊卵巢综合征组与对照组血清 asprosin 水平无显著差异。然而，多囊卵巢综合征 HA 组和胰岛素抵抗组血清 asprosin 水平明显低于相应的多囊卵巢综合征无高雄激素血症组和无胰岛素抵抗组（p<0.05）。在多囊卵巢综合征组中，血清 asprosin 与体重指数、黄体生成素、睾酮、基础窦卵泡数、空腹胰岛素、稳态模型评估的胰岛素抵抗指数和甘油三酯呈负相关。校正体重指数后，相关性无统计学意义，aspirin 仅与催乳素呈正相关（催乳素；r=0.426，p<0.001）。