Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing210023, People's Republic of China.
Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Holistic Integrative Pharmacy Institutes (HIPI), Hangzhou Normal University, Hangzhou311121, People's Republic of China.
J Nat Prod. 2021 Sep 24;84(9):2568-2574. doi: 10.1021/acs.jnatprod.1c00587. Epub 2021 Sep 9.
Twelve guaianolide-type sesquiterpene oligomers with diverse structures were isolated from the whole plants of , including a novel trimer () and two new dimers (, ). The chemical structures of the new compounds were elucidated through spectroscopic data interpretation and computational calculations. Ainsfragolide () is an unusual guaianolide sesquiterpene trimer generated with a novel C-C linkage at C-C, which may be biosynthesized prospectively through a further Michael addition. Cytotoxicity results showed that ainsfragolide () was the most potent compound against five cancer cell lines with IC values in the range of 0.4-8.3 μM.
从全草中分离得到了 12 种具有不同结构的愈创木烷型倍半萜寡聚物，包括一个新的三聚体（）和两个新的二聚体（，）。通过光谱数据分析和计算，阐明了新化合物的化学结构。Ainsfragolide（）是一种不寻常的愈创木烷型倍半萜三聚体，在 C-C 处具有新的 C-C 键连接，可能通过进一步的迈克尔加成进行生物合成。细胞毒性结果表明，ainsfragolide（）对五种癌细胞系的抑制活性最强，IC 值范围为 0.4-8.3 μM。
