Division of Cardiology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Lifespan Cardiovascular Institute, Warren Alpert Medical School at Brown University, 950 Warren Avenue, Suite 201, East Providence, RI, 02914, USA.
J Cardiovasc Magn Reson. 2021 Sep 9;23(1):101. doi: 10.1186/s12968-021-00795-4.
Messenger RNA (mRNA) coronavirus disease of 2019 (COVID-19) vaccine are known to cause minor side effects at the injection site and mild global systemic symptoms in first 24-48 h. Recently published case series have reported a possible association between acute myocarditis and COVID-19 vaccination, predominantly in young males.
We report a case series of 5 young male patients with cardiovascular magnetic resonance (CMR)-confirmed acute myocarditis within 72 h after receiving a dose of an mRNA-based COVID-19 vaccine.
Our case series suggests that myocarditis in this setting is characterized by myocardial edema and late gadolinium enhancement in the lateral wall of the left ventricular (LV) myocardium, reduced global LV longitudinal strain, and preserved LV ejection fraction. All patients in our series remained clinically stable during a relatively short inpatient hospital stay.
In conjunction with other recently published case series and national vaccine safety surveillance data, this case series suggests a possible association between acute myocarditis and COVID-19 vaccination in young males and highlights a potential pattern in accompanying CMR abnormalities.
信使 RNA（mRNA）新冠疫苗已知在接种部位会引起轻微的副作用，并在接种后 24-48 小时内出现轻度全身系统症状。最近发表的病例系列报告称，新冠疫苗接种与急性心肌炎之间可能存在关联，主要发生在年轻男性中。
我们报告了 5 例年轻男性患者的病例系列，他们在接种一剂基于 mRNA 的新冠疫苗后 72 小时内通过心血管磁共振（CMR）确诊为急性心肌炎。
我们的病例系列表明，这种情况下的心肌炎表现为左心室（LV）侧壁心肌水肿和晚期钆增强，左心室整体纵向应变降低，左心室射血分数正常。我们的病例系列中所有患者在相对较短的住院期间临床均保持稳定。
结合其他最近发表的病例系列和国家疫苗安全监测数据，本病例系列提示年轻男性中急性心肌炎与新冠疫苗接种之间可能存在关联，并强调了伴随的 CMR 异常的潜在模式。
