青蒿提取物抗 SARS-CoV-2 的体外疗效。
In vitro efficacy of Artemisia extracts against SARS-CoV-2.
机构信息
Institute for Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7-13, 14163, Berlin, Germany.
Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
出版信息
Virol J. 2021 Sep 8;18(1):182. doi: 10.1186/s12985-021-01651-8.
BACKGROUND
Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19.
METHODS
The plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated.
RESULTS
Several extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability.
CONCLUSIONS
Some plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.
背景
基于草药提取物的传统药物被提议作为治疗因严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）患者的负担得起的方法。含有青蒿和非洲青蒿提取物的茶和饮料已在非洲广泛用于预防 SARS-CoV-2 感染和对抗 COVID-19。
方法
在体外使用猫冠状病毒和 SARS-CoV-2 对产自马达加斯加的植物提取物和 Covid-Organics 饮料进行了抑制病毒斑块形成的测试，并研究了它们的细胞毒性。
结果
几种提取物和 Covid-Organics 均能抑制 SARS-CoV-2 和 FCoV 感染，而不会影响细胞活力。
结论
一些植物提取物对 FCoV 和 SARS-CoV-2 具有抑制活性。然而，尚不清楚在人类中饮用茶或 Covid-Organics 后，血浆中的峰值浓度是否能达到抑制病毒感染所需的水平。需要进行临床研究来评估这些饮料对 COVID-19 的预防或治疗患者的效用。
Zotero 插件