Uslu Sema, Kebapçi Nur, Kara Mehmet, Bal Cengiz
Departments of Medical Biochemistry.
Exp Ther Med. 2012 Jul;4(1):113-120. doi: 10.3892/etm.2012.557. Epub 2012 Apr 23.
The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BMI), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.
本研究旨在探讨2型糖尿病（T2DM）患者血清脂联素、瘦素、抵抗素和内脂素水平与传统及非传统心血管危险因素之间的关系。共有85例T2DM患者和30例非糖尿病对照者纳入本研究。检测了脂肪细胞因子（脂联素、瘦素、抵抗素和内脂素）、脂质（总胆固醇、甘油三酯）、脂蛋白[高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、脂蛋白(a)]、载脂蛋白（载脂蛋白A1和载脂蛋白B）、非传统心血管风险标志物[不对称二甲基精氨酸（ADMA）、同型半胱氨酸]以及炎症标志物超敏C反应蛋白（hs-CRP）的水平，并测定了人体测量学变量。与对照组相比，T2DM患者血清脂联素水平降低，而瘦素、抵抗素和内脂素水平升高。它们与肥胖（BMI）、胰岛素抵抗（HOMA-IR）以及糖/脂代谢、炎症和内皮功能障碍的各种标志物相关。这些结果表明，T2DM患者血清脂联素降低以及瘦素、抵抗素和内脂素水平升高可能是心血管并发症新的生化危险因素。
