Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Department of Basic Medical Sciences, Laboratory of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
World J Gastroenterol. 2021 Aug 14;27(30):5037-5046. doi: 10.3748/wjg.v27.i30.5037.
Inflammatory bowel diseases (IBD) include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated. The intestinal microbiome has been studied as a causal component, with certain microbiotic alterations having been observed in subtypes of IBD. Physical exercise is a modulator of the intestinal microbiome, causing shifts in its composition that are partially corrective of those observed in IBD; furthermore, physical exercise may be beneficial in patients with certain IBD subtypes. This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity's clinical effects on patients with IBD.
炎症性肠病（IBD）包括一系列慢性胃肠道炎症性疾病，其发病机制尚未阐明。肠道微生物组已被研究为一个致病因素，在 IBD 的某些亚型中观察到了某些微生物的改变。体育锻炼是肠道微生物组的调节剂，它导致其组成发生变化，部分纠正了 IBD 中观察到的变化；此外，体育锻炼可能对某些 IBD 亚型的患者有益。本综述研究了体育锻炼对人类肠道微生物组的影响，同时研究了可以解释体育活动对 IBD 患者临床效果的病理生理机制。
