营养与身体活动与肠道微生物群有关吗？一项对健康年轻成年人样本的初步研究。

Are nutrition and physical activity associated with gut microbiota? A pilot study on a sample of healthy young adults.

机构信息

Public Health Unit, University of Rome "Foro Italico", Rome, Italy.

Department of Movement Sciences and Wellbeing, University "Parthenope", Naples, Italy.

出版信息

Ann Ig. 2020 Sep-Oct;32(5):521-527. doi: 10.7416/ai.2020.2372.

DOI:10.7416/ai.2020.2372

PMID:32744583

Abstract

BACKGROUND

The literature shows that gut microbiota composition is related with health, and a lot of individual and outer factors may determine its variability. In particular, nutrition and exercise seem to influence the presence in the gut of the two major bacterial phyla of Firmicutes and Bacteroidetes.

STUDY DESIGN

An ongoing cross-sectional investigation is aimed to explore these associations in humans.

METHODS

Healthy Caucasian young adults were asked to provide a fecal sample in order to analyze their gut microbiome considering their Body Mass Index (BMI), adherence to Mediterranean diet and Physical Activity (PA) level.

RESULTS

A total of 59 participants (49.1% males, mean age 23.1 ± 3.14 years) were enrolled so far. Firmicutes (61.6±14.6) and Bacteroidetes (30.7 ± 13.3) showed the highest relative abundance in fecal samples. The Pearson's analysis showed a significant negative correlation between PA and Firmicutes (r =-0.270, p = 0.03). Linear regression confirmed a significant decrease of this phylum with the increase of PA (R2 = 0.07, p = 0.03).

CONCLUSIONS

These preliminary results suggest the association between physical activity and gut microbiota composition in healthy humans.

摘要

背景

文献表明，肠道微生物群落的组成与健康有关，许多个体和外部因素可能决定其可变性。特别是，营养和运动似乎会影响厚壁菌门和拟杆菌门这两个主要细菌门在肠道中的存在。

研究设计

目前正在进行一项横断面研究，旨在探索这些在人类中的关联。

方法

要求健康的白种年轻人提供粪便样本，以分析他们的肠道微生物组，同时考虑他们的体重指数（BMI）、对地中海饮食的坚持程度和身体活动（PA）水平。

结果

迄今为止，共纳入了 59 名参与者（男性占 49.1%，平均年龄 23.1 ± 3.14 岁）。粪便样本中Firmicutes（61.6±14.6）和Bacteroidetes（30.7 ± 13.3）的相对丰度最高。Pearson 分析显示，PA 与Firmicutes 呈显著负相关（r =-0.270，p = 0.03）。线性回归证实，随着 PA 的增加，该门的数量显著减少（R2 = 0.07，p = 0.03）。