单腿站立时间可独立于临床危险因素和 BMD 预测老年女性的骨折风险。
One leg standing time predicts fracture risk in older women independent of clinical risk factors and BMD.
机构信息
Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Department of Orthopaedics, Sahlgrenska University Hospital, Mölndal, Sweden.
出版信息
Osteoporos Int. 2022 Jan;33(1):185-194. doi: 10.1007/s00198-021-06039-6. Epub 2021 Sep 8.
UNLABELLED
In women of ages 75-80 years, a low one leg standing time (OLST) was associated with an increased risk of incident fractures, independently of bone mineral density and clinical risk factors. OLST contributed substantially to fracture probability, indicating that the test should be considered when evaluating fracture risk in older women.
INTRODUCTION
Physical function and risk of falls are important risk factors for fracture. A few previous studies have suggested that a one leg standing time (OLST) less than 10 s predicts fracture risk, but the impact of OLST, in addition to known clinical risk factors, for fracture probability is unknown. The aim of this study was to determine the independent contribution of OLST to fracture probability in older women.
METHODS
The Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures (SUPERB) is a prospective population-based study of 3028 women 75-80 years old, recruited from the greater Gothenburg area in Sweden. At baseline, information on risk factors was collected using questionnaires, bone mineral density was measured with dual-energy X-ray absorptiometry (DXA), and OLST was performed.
RESULTS
During a median follow-up of 3.6 years (IQR 1.5 years), X-ray-verified incident fractures were identified using health records. OLST was available in 2405 women. OLST less than 10 s was associated with an increased risk for incident hip fracture (Hazard Ratio (HR) 3.02, 95% Confidence Interval (CI) [1.49-6.10]), major osteoporotic fracture (HR 95% CI 1.76 [1.34-1.46]), and nonvertebral fracture (HR 95% CI 1.61 [1.26-2.05]) in Cox regression analyses adjusted for age, height, and weight. Depending on BMD, the 4-year fracture probability increased by a factor of 1.3 to 1.5 in a 75-year-old woman with a low OLST (<10 s).
CONCLUSION
A low OLST has a substantial impact on fracture probability and should be considered when evaluating fracture risk in older women.
非特定
在 75-80 岁的女性中，单腿站立时间（OLST）较短与骨折发生率增加相关，独立于骨密度和临床危险因素。OLST 对骨折概率有很大贡献，表明在评估老年女性的骨折风险时应考虑该测试。
引言
身体功能和跌倒风险是骨折的重要危险因素。一些先前的研究表明，单腿站立时间（OLST）小于 10 秒可以预测骨折风险，但 OLST 除了已知的临床危险因素外，对骨折概率的影响尚不清楚。本研究的目的是确定 OLST 对老年女性骨折概率的独立贡献。
方法
萨赫勒格伦斯卡大学医院骨折风险的前瞻性评估（SUPERB）是一项针对瑞典哥德堡地区的 3028 名 75-80 岁女性的前瞻性人群研究。在基线时，使用问卷调查收集了危险因素信息，使用双能 X 射线吸收法（DXA）测量了骨密度，并进行了 OLST。
结果
在中位随访 3.6 年（IQR 1.5 年）期间，通过健康记录确定了 X 射线证实的新发骨折。在 2405 名女性中可以获得 OLST。OLST 小于 10 秒与髋部骨折（风险比（HR）95%置信区间（CI）[1.49-6.10]）、主要骨质疏松性骨折（HR 95% CI [1.76-1.46]）和非椎体骨折（HR 95% CI [1.61-1.26]）的发生风险增加相关，在 Cox 回归分析中调整了年龄、身高和体重。根据 BMD，在 75 岁女性中，OLST 较低（<10 秒）的情况下，4 年内骨折的概率增加了 1.3 至 1.5 倍。
结论
OLST 较短对骨折概率有很大影响，在评估老年女性的骨折风险时应考虑该测试。
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