Kanis John A, Harvey Nicholas C, Johansson Helena, Odén Anders, Leslie William D, McCloskey Eugene V
Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK; Institute of Health and Ageing, Australian Catholic University, Melbourne, Australia.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
J Clin Densitom. 2017 Jul-Sep;20(3):360-367. doi: 10.1016/j.jocd.2017.06.022. Epub 2017 Jul 18.
The fracture risk assessment tool, FRAX, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, models are now available for 63 countries, covering 79% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. However, the application of FRAX in guidelines has been heterogeneous with the adoption of several different approaches to setting intervention thresholds. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future. A more unified approach to setting intervention thresholds with FRAX is a research priority.
骨折风险评估工具FRAX于2008年发布，提供针对特定国家的算法，用于估计个体发生髋部骨折和主要骨质疏松性骨折（髋部、临床椎体、桡骨远端和肱骨近端）的10年概率。自发布以来，目前已有63个国家的模型，覆盖全球79%的人口。该网站每年约有300万次访问量。经过独立验证后，FRAX已被纳入全球80多项指南。然而，FRAX在指南中的应用存在异质性，采用了几种不同的方法来设定干预阈值。FRAX与干预效果之间的关系已得到探讨，预计未来将影响治疗指南。采用更统一的方法利用FRAX设定干预阈值是一项研究重点。
