• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter.

作者信息

Donovan Killian, Meli Athinoula, Cendali Francesca, Park Kyung Chan, Cardigan Rebecca, Stanworth Simon, McKechnie Stuart, D'Alessandro Angelo, Smethurst Peter A, Swietach Pawel

机构信息

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford.

Component Development Laboratory, NHS Blood and Transplant, Cambridge.

出版信息

Haematologica. 2022 Jan 1;107(1):298-302. doi: 10.3324/haematol.2021.279296.

DOI:10.3324/haematol.2021.279296
PMID:34498445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8719080/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/ab560677dc08/107298.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/3b47f71a0b40/107298.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/cabe7726cb14/107298.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/ab560677dc08/107298.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/3b47f71a0b40/107298.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/cabe7726cb14/107298.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9f3/8719080/ab560677dc08/107298.fig3.jpg

相似文献

1
Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter.储存的血液存在氧卸载动力学受损的情况，这种情况可通过复壮使其正常化，并且可从细胞侧向散射进行预测。
Haematologica. 2022 Jan 1;107(1):298-302. doi: 10.3324/haematol.2021.279296.
2
Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood.使用FlowScore（一种流式细胞术检测的血液功能质量替代指标）评估红细胞的氧卸载动力学。
EBioMedicine. 2025 Jan;111:105498. doi: 10.1016/j.ebiom.2024.105498. Epub 2024 Dec 14.
3
Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells.低氧储存条件下的代谢重编程可保持储存的红细胞更快地释放氧气。
Blood Adv. 2022 Sep 27;6(18):5415-5428. doi: 10.1182/bloodadvances.2022007774.
4
Rejuvenation treatment of stored red blood cells reverses storage-induced adhesion to vascular endothelial cells.储存红细胞的复苏处理可逆转储存诱导的对血管内皮细胞的黏附。
Transfusion. 2009 Oct;49(10):2136-43. doi: 10.1111/j.1537-2995.2009.02251.x. Epub 2009 Jun 15.
5
[Method of restoration (rejuvenation) of preserved erythrocytes stored over the maximum period of time].
Sov Med. 1976 Aug(8):66-9.
6
Rejuvenation of stored human red blood cells reverses the renal microvascular oxygenation deficit in an isovolemic transfusion model in rats.储存人红细胞的复苏可逆转大鼠等容输血模型中的肾微血管氧合不足。
Transfusion. 2009 Mar;49(3):427-4. doi: 10.1111/j.1537-2995.2008.02002.x. Epub 2008 Nov 25.
7
Metabolic rejuvenation upgrades circulatory functions of red blood cells stored under blood bank conditions.代谢重编程可提升血库条件下储存的红细胞的循环功能。
Transfusion. 2021 Mar;61(3):903-918. doi: 10.1111/trf.16245. Epub 2020 Dec 31.
8
Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.4°C和37°C下早期储存红细胞复苏的代谢组学评估
Transfusion. 2018 Aug;58(8):1980-1991. doi: 10.1111/trf.14623. Epub 2018 Apr 24.
9
Rejuvenation and freezing of outdated stored human red cells.
N Engl J Med. 1972 Dec 28;287(26):1307-13. doi: 10.1056/NEJM197212282872601.
10
Rejuvenation improves roller pump-induced physical stress resistance of fresh and stored red blood cells.复壮可提高新鲜和储存的红细胞对滚压泵引起的物理应激的抵抗力。
Transfusion. 2011 May;51(5):1096-104. doi: 10.1111/j.1537-2995.2010.02972.x. Epub 2010 Dec 6.

引用本文的文献

1
Red blood cell metabolism: a window on systems health towards clinical metabolomics.红细胞代谢：通往临床代谢组学的系统健康之窗。
Curr Opin Hematol. 2025 May 1;32(3):111-119. doi: 10.1097/MOH.0000000000000863. Epub 2025 Mar 13.
2
Supercooled storage of red blood cells slows down the metabolic storage lesion.红细胞的过冷储存可减缓代谢性储存损伤。
Res Sq. 2025 Feb 27:rs.3.rs-5256734. doi: 10.21203/rs.3.rs-5256734/v1.
3
Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood.

本文引用的文献

1
Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform.利用微流控分析平台评估单个红细胞氧扩散的瞬态变化。
Commun Biol. 2021 Mar 2;4(1):271. doi: 10.1038/s42003-021-01793-z.
2
Single-cell O exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells.单细胞 O 交换成像显示，细胞质扩散是红细胞中有效气体传输的主要障碍。
Proc Natl Acad Sci U S A. 2020 May 5;117(18):10067-10078. doi: 10.1073/pnas.1916641117. Epub 2020 Apr 22.
3
Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity.
使用FlowScore（一种流式细胞术检测的血液功能质量替代指标）评估红细胞的氧卸载动力学。
EBioMedicine. 2025 Jan;111:105498. doi: 10.1016/j.ebiom.2024.105498. Epub 2024 Dec 14.
4
Ferroptosis regulates hemolysis in stored murine and human red blood cells.铁死亡调节储存的小鼠和人类红细胞中的溶血。
Blood. 2025 Feb 13;145(7):765-783. doi: 10.1182/blood.2024026109.
5
It's in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism.在你的血液中：年龄、性别、遗传因素和暴露因素对储存的红细胞代谢的影响。
Transfus Apher Sci. 2024 Dec;63(6):104011. doi: 10.1016/j.transci.2024.104011. Epub 2024 Oct 15.
6
Effect of storage duration on outcome of patients receiving red blood cell in emergency department.储存时间对急诊科接受红细胞输注患者结局的影响。
Sci Rep. 2024 Oct 8;14(1):23463. doi: 10.1038/s41598-024-74114-z.
7
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.糖酵解的生物学和遗传决定因素：磷酸果糖激酶同工型可提高储存红细胞的能量状态及输血效果。
Cell Metab. 2024 Sep 3;36(9):1979-1997.e13. doi: 10.1016/j.cmet.2024.06.007. Epub 2024 Jul 3.
8
Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport.红细胞氧运输的变构和血管调节机制的调节。
Front Physiol. 2024 Jun 10;15:1394650. doi: 10.3389/fphys.2024.1394650. eCollection 2024.
9
Heavy metals in red blood cells: From "Iron Maiden" to "Lead" Zeppelin.红细胞中的重金属：从“铁娘子”到“齐柏林飞艇”
Transfusion. 2024 Jul;64(7):1181-1183. doi: 10.1111/trf.17912. Epub 2024 Jun 7.
10
Effect of leukoreduction on the omics phenotypes of canine packed red blood cells during refrigerated storage.白细胞滤减法对冷藏保存期间犬浓缩红细胞组学表型的影响。
J Vet Intern Med. 2024 May-Jun;38(3):1498-1511. doi: 10.1111/jvim.17031. Epub 2024 Mar 29.
供者的性别、年龄和种族通过部分由葡萄糖-6-磷酸脱氢酶水平和活性解释的机制影响储存的红细胞抗氧化代谢。
Haematologica. 2021 May 1;106(5):1290-1302. doi: 10.3324/haematol.2020.246603.
4
Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage.恒河猴和人类的红细胞代谢：血液储存的比较生物学。
Haematologica. 2020 Aug;105(8):2174-2186. doi: 10.3324/haematol.2019.229930. Epub 2019 Nov 7.
5
Rejuvenation of RBCs: validation of a manufacturing method suitable for clinical use.红细胞的复壮：一种适合临床应用的制造方法的验证。
Transfusion. 2019 Sep;59(9):2952-2963. doi: 10.1111/trf.15426. Epub 2019 Jul 11.
6
Can we be certain that storage duration of transfused red blood cells does not affect patient outcomes?我们能否确定输注的红细胞的储存时间不会影响患者的治疗结果？
BMJ. 2019 Jun 11;365:l2320. doi: 10.1136/bmj.l2320.
7
Red blood cell storage lesion: causes and potential clinical consequences.红细胞储存损伤：原因及潜在临床后果。
Blood Transfus. 2019 Jan;17(1):27-52. doi: 10.2450/2019.0217-18.
8
Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.评估红细胞输血阈值的临床试验：一项更新的系统评价，重点关注心血管疾病患者。
Am Heart J. 2018 Jun;200:96-101. doi: 10.1016/j.ahj.2018.04.007. Epub 2018 Apr 7.
9
Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis.红细胞输注的红细胞年龄对患者结局的影响：系统评价和荟萃分析。
Transfus Med Rev. 2018 Apr;32(2):77-88. doi: 10.1016/j.tmrv.2018.02.002. Epub 2018 Feb 17.
10
Spherocytic shift of red blood cells during storage provides a quantitative whole cell-based marker of the storage lesion.储存期间红细胞的球形转变提供了一种基于全细胞的储存损伤定量标志物。
Transfusion. 2017 Apr;57(4):1007-1018. doi: 10.1111/trf.14015. Epub 2017 Feb 1.