Guizhou University of Traditional Chinese Medicine, Guiyang, P. R. China.
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong.
Nat Prod Res. 2023 Jan;37(1):68-76. doi: 10.1080/14786419.2021.1950716. Epub 2021 Sep 9.
A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A ()], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B ()], along with two known compounds ( and ) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal . Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC value of 108.5 μM.
从民间药用植物的嫩枝和叶甲醇提取物中分离得到了一种新的伊克替烷二萜，11,12,20α-三羟基-7β-甲氧基伊克替烷-8,11,13-三烯-19,10-内酯[Phyllane A()]和一种新的扁柏烷二萜，7β,20-环氧-3β,17-乙酰氧基-扁柏烷-8,11,13-三烯-11,12-二醇[phyllane B()]，以及两种已知化合物()。它们的结构通过包括 2D NMR 光谱数据在内的光谱分析确定，并通过 X 射线单晶衍射进一步证实。此外，对化合物进行了细胞毒性和抗 HIV 活性评价，发现 phyllane A 对 HIV 具有抗活性，IC 值为 15.7μM，而 phyllane B 对 A549 宿主细胞具有细胞毒性，CC 值为 108.5μM。
