小胶质细胞上的PICK1/TLR4复合物参与脂多糖诱导的脓毒症相关性脑病的调控。
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy.
作者信息
Wang Lu, Lin Feihong, Ren Miao, Liu Xia, Xie Wenjing, Zhang Anqi, Qian Meizi, Mo Yunchang, Wang Junlu, Lv Ya
机构信息
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, Zhejiang 325000, PR China; Department of Anesthesiology,The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, PR China.
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, Zhejiang 325000, PR China.
出版信息
Int Immunopharmacol. 2021 Nov;100:108116. doi: 10.1016/j.intimp.2021.108116. Epub 2021 Sep 6.
The treatment options for sepsis-associated encephalopathy caused by systemic inflammation are still not sufficient. Protein kinase C interaction protein 1 (PICK1) has attracted much attention because of its important physiological functions in many tissues. However, its role in sepsis-associated encephalopathy remains elusive. Our study results revealed that the expression levels of PICK1 protein in mice with lipopolysaccharide-induced sepsis-associated encephalopathy were not significantly changed, but PICK1 deficiency led to excessive activation of microglia and Toll-like receptor (TLR)4 pathways, which aggravated the sepsis- associated encephalopathy. We also observed that PICK1 and TLR4 form a complex in microglial cells, thereby providing brain protection. These findings contribute to our understanding of the important role of PICK1 in sepsis and may provide novel therapeutic targets to treat sepsis-associated encephalopathy.
由全身炎症引起的脓毒症相关性脑病的治疗选择仍然不足。蛋白激酶C相互作用蛋白1（PICK1）因其在许多组织中的重要生理功能而备受关注。然而，其在脓毒症相关性脑病中的作用仍不清楚。我们的研究结果显示，脂多糖诱导的脓毒症相关性脑病小鼠中PICK1蛋白的表达水平没有显著变化，但PICK1缺乏导致小胶质细胞和Toll样受体（TLR）4通路过度激活，从而加重了脓毒症相关性脑病。我们还观察到PICK1和TLR4在小胶质细胞中形成复合物，从而提供脑保护。这些发现有助于我们理解PICK1在脓毒症中的重要作用，并可能为治疗脓毒症相关性脑病提供新的治疗靶点。
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