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结构、生物活性和分析方法测定皂苷。

Structure, Bioactivity and Analytical Methods for the Determination of Saponins.

机构信息

Allelopathy Group, Department of Organic Chemistry, Campus de Excelencia Internacional (ceiA3), Institute of Biomolecules (INBIO), School of Science, University of Cadiz, c/República Saharaui 7, 11510 Puerto Real, Spain.

出版信息

Molecules. 2021 Aug 30;26(17):5251. doi: 10.3390/molecules26175251.

Abstract

is one of the main sources of steroidal saponins, hence different extracts are commercialized for use as surfactant additives by beverage, animal feed, cosmetics or agricultural products. For a deeper understanding of the potential of the saponins that can be found in this genus, an exhaustive review of the structural characteristics, bioactivities and analytical methods that can be used with these compounds has been carried out, since there are no recent reviews on the matter. Thus, a total of 108 saponins from eight species of the genus have been described. Out of these, the bioactivity of 68 saponins derived from the isolation of or other genera has been evaluated. Regarding the evaluation and quality control of the saponins from this genus LC-MS technique is the most often used. Nevertheless, the development of methods for their routine analysis in commercial preparations are needed. Moreover, most of the studies found in the literature have been carried out on extract, since is the most often used for commercial purposes. Only eight of the 50 species that belong to this genus have been studied, which clearly indicates that the identification of saponins present in genus is still an unresolved question.

摘要

是甾体皂苷的主要来源之一,因此不同的提取物被商业化用作饮料、动物饲料、化妆品或农产品的表面活性剂添加剂。为了更深入地了解该属中可能存在的皂苷的潜力,对可以用于这些化合物的结构特征、生物活性和分析方法进行了全面的综述,因为目前没有关于该主题的最新综述。因此,总共描述了来自该属的 8 个种的 108 种皂苷。其中,对 68 种从分离得到的皂苷的生物活性进行了评价。关于该属的皂苷的评价和质量控制,LC-MS 技术是最常用的。然而,需要开发用于其在商业制剂中的常规分析的方法。此外,文献中发现的大多数研究都是在 提取物上进行的,因为它是最常用于商业目的的。该属中属于这一属的 50 个种中只有 8 个得到了研究,这清楚地表明,鉴定 属中存在的皂苷仍然是一个悬而未决的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cc/8433717/78aef0306691/molecules-26-05251-g001.jpg

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