Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.
Scientific Research Department, Nanjing Tech University, Nanjing 211816, China.
Molecules. 2021 Sep 2;26(17):5336. doi: 10.3390/molecules26175336.
Metal-organic frameworks (MOFs) have been demonstrated to be desired candidates for sensing definite species owing to their tunable composition, framework structure and functionality. In this work, the NH-MIL-101 series was utilized for sensing specific amino acids. The results show that cysteine (Cys) can significantly enhance the fluorescence emission of NH-MIL-101-Fe suspended in water, while NH-MIL-101-Al exhibits the ability to sense lysine (Lys), arginine (Arg) and histidine (His) in aqueous media via turn-on fluorescence emission. Titration experiments ensure that NH-MIL-101-Fe and NH-MIL-101-Al can selectively and quantitatively detect these amino acids. The sensing mechanism was examined and discussed. The results of this study show that the metal centers in MOFs are crucial for sensing specific amino acids.
金属-有机骨架（MOFs）由于其可调节的组成、骨架结构和功能，已被证明是用于感应特定物质的理想候选物。在这项工作中，利用 NH-MIL-101 系列来感应特定的氨基酸。结果表明，半胱氨酸（Cys）可以显著增强在水中悬浮的 NH-MIL-101-Fe 的荧光发射，而 NH-MIL-101-Al 则具有通过开启荧光发射感应水溶液中赖氨酸（Lys）、精氨酸（Arg）和组氨酸（His）的能力。滴定实验确保 NH-MIL-101-Fe 和 NH-MIL-101-Al 可以选择性和定量地检测这些氨基酸。对感应机制进行了研究和讨论。研究结果表明，MOFs 中的金属中心对于感应特定的氨基酸是至关重要的。
